Comprehensive Synthesis of Photoreactive (3-Trifluoromethyl)diazirinyl Indole Derivatives from 5- and 6-Trifluoroacetylindoles for Photoaffinity Labeling

被引：29
|
作者：
Murai, Yuta [1 ]
Masuda, Katsuyoshi
Sakihama, Yasuko [1 ]
Hashidoko, Yasuyuki [1 ]
Hatanaka, Yasumaru [2 ]
Hashimoto, Makoto [1 ]
机构：
[1] Hokkaido Univ, Grad Sch Agr, Kita Ku, Sapporo, Hokkaido 0608589, Japan
[2] Toyama Univ, Grad Sch Med & Pharmaceut Sci, Toyama 9300194, Japan
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 19期
关键词：
EFFICIENT SYNTHESIS; ACID; CHEMISTRY; TRYPTOPHAN; DISCOVERY; LIGANDS; POTENT;
D O I：
10.1021/jo301552m
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
5- and 6-trifluoromethyldiazirinyl indoles were synthesized from corresponding bromoindole derivatives for the first time. They acted as mother skeletons for the comprehensive synthesis of various bioactive indole metabolites. These can be used in biological functional analysis as diazirine-based photoaffinity labels.
引用
收藏
页码：8581 / 8587
页数：7
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