Ursolic Acid Inhibits Tumor Growth via Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cells

被引：23
|
作者：
Wang, Xianmin [1 ]
Wang, Ting [2 ]
Yi, Fan [3 ]
Duan, Chunyan [4 ]
Wanwg, Qiaoling [4 ]
He, Nana [4 ]
Zhu, Lei [5 ]
Li, Qi [2 ]
Deng, Wanli [2 ,4 ]
机构：
[1] Xinjiang Med Univ, Tradit Chinese Med Hosp Affiliated, Dept Tradit Chinese Med, Xinjiang 830000, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Med Oncol, Shanghai 201203, Peoples R China
[3] Urumqi Hosp Tradit Chinese Med, Dept Digest Dis, Urumqi 830000, Xinjiang, Peoples R China
[4] Xinjiang Med Univ, Tradit Chinese Med Hosp Affiliated, Oncol Dept 1, Xinjiang 830000, Peoples R China
[5] Changji Tradit Chinese Med Hosp Xinjiang, Dept Internal Med 4, Xinjiang 830054, Peoples R China
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2019年 / 42卷 / 05期
基金：
中国国家自然科学基金;
关键词：
colorectal cancer; epithelial-mesenchymal transition; metastasis; ursolic acid; invasion; DERIVATIVES; CHEMOSENSITIZATION; PROLIFERATION; METASTASIS;
D O I：
10.1248/bpb.b18-00613
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Ursolic acid (UA), a natural pentacyclic triterpenoid, is a promising compound for cancer prevention and therapy. However, its mechanisms of action have not been well elucidated in colorectal cancer cells. Here, using cultured human colon cancer cell lines SW620 and HCT116, this assay demonstrates that UA reduces cell viability, inhibits cell clone formation, and induces caspase-3 mediated apoptosis. Additional experiments show that UA inhibits cell migration and epithelial-mesenchymal transition (EMT), including E-cadherin, Vimentin, Integrin, Twist, and Zeb1 biomakers. These results suggest that UA inhibits cell proliferation, invasion, and metastasis in colorectal cancer cells by affecting mechanisms that regulate EMT. Taken together, the results suggested that the anti-proliferation and anti-metastasis activities of UA was through EMT inhibition in colorectal cancer.
引用
收藏
页码：685 / 691
页数：7
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