Optogenetic stimulation of the auditory pathway for research and future prosthetics

被引：45
|
作者：
Moser, Tobias [1 ,2 ,3 ,4 ]
机构：
[1] Univ Med Ctr Gottingen, Inst Auditory Neurosci, Gottingen, Germany
[2] Univ Med Ctr Gottingen, Collaborat Res Ctr 889, Gottingen, Germany
[3] Univ Gottingen, Bernstein Ctr Computat Neurosci, D-37073 Gottingen, Germany
[4] Univ Gottingen, Ctr Nanoscale Microscopy & Mol Physiol Brain, D-37073 Gottingen, Germany
来源：
CURRENT OPINION IN NEUROBIOLOGY | 2015年 / 34卷
关键词：
LIGHT-INDUCED ACTIVATION; COCHLEAR IMPLANTS; LASER STIMULATION; INFERIOR COLLICULUS; NEURAL STIMULATION; TRANSGENIC MICE; GENE-TRANSFER; NERVE; MOUSE; EXCITATION;
D O I：
10.1016/j.conb.2015.01.004
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Sound is encoded by spiral ganglion neurons (SGNs) in the hearing organ, the cochlea, with great temporal, spectral and intensity resolution. When hearing fails, electric stimulation by implanted prostheses can partially restore hearing. Optical stimulation promises a fundamental advance of hearing restoration over electric prostheses since light can be conveniently focused and hence might dramatically improve frequency resolution of sound encoding. Combining optogenetic manipulation of neurons with innovative optical stimulation technology promises versatile spatiotemporal stimulation patterns in the auditory system. Therefore, using optical stimulation of SGNs also has great potential for auditory research. Here, I review recent progress in optogenetic stimulation of the auditory system and its potential for future application in research and hearing restoration.
引用
收藏
页码：29 / 36
页数：8
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