Nuclear Hormone Receptor Regulation of MicroRNAs Controls Innate Immune Responses in C. elegans

被引：23

作者：

Liu, Feng ^{[1
,2
]}

He, Chen-Xi ^{[3
]}

Luo, Li-Jun ^{[1
]}

Zou, Quan-Li ^{[1
]}

Zhao, Yong-Xu ^{[1
]}

Saini, Ratni ^{[4
]}

Han, San-Feng ^{[5
]}

Knoelker, Hans-Joachim ^{[4
]}

Wang, Li-Shun ^{[5
]}

Ge, Bao-Xue ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Jiao Tong Univ, Inst Hlth Sci,Sch Med, Shanghai, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

[3] Tongji Univ, Sch Med, Shanghai Pulm Hosp, Clin & Translat Res Ctr,Shanghai Key Lab TB, Shanghai 200092, Peoples R China

[4] Tech Univ Dresden, Dept Chem, Dresden, Germany

[5] Shanghai Jiao Tong Univ, Sch Med, Chinese Minist Educ, Key Lab Cell Differentiat & Apoptosis, Shanghai 200030, Peoples R China

来源：

PLOS PATHOGENS | 2013年 / 9卷 / 08期

基金：

中国国家自然科学基金;

关键词：

CAENORHABDITIS-ELEGANS; LIFE-SPAN; LARVAL DEVELOPMENT; DEVELOPMENTAL AGE; DAUER FORMATION; DAF-12; SIGNALS; GENES; REPRODUCTION; METABOLISM;

D O I：

10.1371/journal.ppat.1003545

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nuclear hormone receptors respond to small molecules such as retinoids or steroids and regulate development. Signaling in the conserved p38/PMK-1 MAP kinase pathway regulates innate immunity. In this study, we show that the Caenorhabditis elegans nuclear receptor DAF-12 negatively regulates the defense against pathogens via the downstream let-7 family of microRNAs, which directly target SKN-1, a gene downstream of PMK-1. These findings identify nuclear hormone receptors as components of innate immunity that crosstalk with the p38/PMK-1 MAP kinase pathway.

引用

页数：14

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