Inhibition of Histone Deacetylase 6 (HDAC6) Disrupts the Tolerogenic STAT3 Signaling Pathway and Augments Antitumor Immune Responses in Mantle Cell Lymphoma (MCL)

被引:0
|
作者
Wang, Hongwei [1 ]
Cheng, Fengdong [1 ]
Wang, Zi [1 ]
Lienlaf, Maritza [1 ]
Perez-Villarroel, Patricio [1 ]
Knox, Tessa [1 ]
Sahakian, Eva [1 ]
Pinilla-Ibarz, Javier [1 ]
Horna, Pedro [1 ]
Chen-Kiang, Selina [2 ]
Martin, Peter [2 ]
Bergman, Joel [3 ]
Kozikowski, Alan [3 ]
Villagra, Alejandro [1 ]
Tao, Jianguo [1 ]
Shah, Bijal D. [1 ]
Sotomayor, Eduardo M. [1 ]
机构
[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
[2] Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY USA
[3] Univ Illinois Chicago Coll Pharm, Chicago, IL USA
关键词
D O I
10.1182/blood.V120.21.3724.3724
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
3724
引用
收藏
页数:2
相关论文
共 50 条
  • [32] Interleukin-6 induces prostate cancer cell growth accompanied by activation of Stat3 signaling pathway
    Lou, W
    Ni, ZY
    Dyer, K
    Tweardy, DJ
    Gao, AC
    [J]. PROSTATE, 2000, 42 (03): : 239 - 242
  • [33] Interferon alpha induces cell death through interference with interleukin 6 signaling and inhibition of STAT3 activity
    Thyrell, Lena
    Arulampalam, Velmurugesan
    Hjortsberg, Linn
    Farnebo, Marianne
    Grander, Dan
    Tamm, Katja Pokrouskaja
    [J]. EXPERIMENTAL CELL RESEARCH, 2007, 313 (19) : 4015 - 4024
  • [34] Chidamide, a Novel Histone Deacetylase Inhibitor, Displays Potent Antitumor Activity Against MDS Cells Mainly through JAK2/STAT3 Signaling Inhibition
    Chang, Chunkang
    Zhao, Sida
    Guo, Juan
    Zhao, Youshan
    Fei, Chengming
    Gu, Shucheng
    Li, Xiao
    [J]. BLOOD, 2015, 126 (23)
  • [35] IL-6/STAT3 Pathway in B Cell Gammaherpesvirus Latency and Myc-Driven B Cell Lymphoma
    Marshall, Nancy C. Reich
    Petrenko, Alexei
    Reddy, Sandeep
    Foreman, Hui-Chen
    Sioux, Ozula
    Park, Gee Ho
    Poli, Valeria
    Krug, Laurie
    [J]. CYTOKINE, 2015, 76 (01) : 72 - 72
  • [36] G6PD downregulation triggered growth inhibition and induced apoptosis by regulating STAT3 signaling pathway in esophageal squamous cell carcinoma
    Wang, Xin
    Liu, Hongtao
    Zhang, Xiaqing
    Li, Xiaojuan
    Gu, Hao
    Zhang, Heng
    Fan, Ruitai
    [J]. TUMOR BIOLOGY, 2016, 37 (01) : 781 - 789
  • [37] Notch Regulation Of Cell Density-Dependent Apoptosis Via Il-6/stat3 Signaling Pathway
    Matsuno, Y.
    Jarai, G.
    Hizawa, N.
    Hogaboam, C. M.
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2014, 189
  • [38] Hedgehog signaling pathway regulates Th17 cell differentiation in asthma via IL-6/STAT3 signaling
    Jin, Yuting
    Pan, Zhenzhen
    Zhou, Ji
    Wang, Kai
    Zhu, Peijie
    Wang, Yufeng
    Xu, Xuena
    Zhang, Jinping
    Hao, Chuangli
    [J]. INTERNATIONAL IMMUNOPHARMACOLOGY, 2024, 139
  • [39] Embelin Promotes Oncolytic Vaccinia Virus-Mediated Antitumor Immunity Through Disruption of IL-6/STAT3 Signaling in Lymphoma
    Wang, Peng
    Wu, Yi
    Yang, Chen
    Zhao, Guanan
    Liu, Yonghua
    Cheng, Gang
    Wang, Shibing
    [J]. ONCOTARGETS AND THERAPY, 2020, 13 : 1421 - 1429
  • [40] STAT3 Activation Is Preceded By Two Independent Pathways (BCR-BTK and IL6-JAK) in Mantle Cell Lymphoma
    Park, Hyebin
    Zhao, Donglu
    Tsourdinis, George
    Ou, Zhishuo
    Tamayo, Archito T.
    Ford, Richard J.
    Fang, Bingliang
    Pham, Lan V.
    Zhang, Liang
    Wang, Michael
    [J]. BLOOD, 2014, 124 (21)