Palladium-Catalyzed Double Alkylation of 3-Aryl-2-fluoroallyl Esters with Malonate Nucleophiles through the Carbon-Fluorine Bond Cleavage

被引：24
|
作者：
Yamamoto, Mitsuaki [1 ]
Hayashi, Shunsuke [1 ]
Isa, Kazuki [1 ]
Kawatsura, Motoi [1 ]
机构：
[1] Nihon Univ, Dept Chem, Coll Humanities & Sci, Setagaya Ku, Tokyo 1568550, Japan
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 03期
基金：
日本学术振兴会;
关键词：
SUBSTITUTED ALLYLIC AMINES; KETENE SILYL ACETALS; REGIOSELECTIVE SYNTHESIS; TRIFLUOROMETHYL GROUP; (PI-ALLYL)PALLADIUM COMPLEXES; PHENOXIDE ION; ATTACK; CYCLOPROPANATION; ATOM; REGIOCHEMISTRY;
D O I：
10.1021/ol500121z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The alkylation of (Z)-3-aryl-2-fluoroallyl acetate with the malonate anion by the [Pd(C3H5)(cod)]BF4/2,2'-bpy catalyst proceeds through the carbon fluorine bond cleavage, and 2 equiv of the malonate nucleophile was introduced to the allyl substrate.
引用
收藏
页码：700 / 703
页数：4
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