Design, synthesis and molecular simulation studies of dihydrostilbene derivatives as potent tyrosinase inhibitors

被引：36

作者：

Vontzalidou, Argyro ^{[1
]}

Zoidis, Grigoris ^{[1
,2
]}

Chaita, Eliza ^{[1
]}

Makropoulou, Maria ^{[1
]}

Aligiannis, Nektarios ^{[1
]}

Lambrinidis, George ^{[2
]}

Mikros, Emmanuel ^{[2
]}

Skaltsounis, Alexios-Leandros ^{[1
]}

机构：

[1] Univ Athens, Fac Pharm, Dept Pharmacognosy & Nat Prod Chem, GR-15771 Athens, Greece

[2] Univ Athens, Fac Pharm, Dept Pharmaceut Chem, GR-15771 Athens, Greece

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 17期

关键词：

Deoxybenzoins; Dihydrostilbenes; Tyrosinase inhibitors; Kojic acid; Gallic acid; Molecular simulations; IDENTIFICATION; DOPAMINE;

D O I：

10.1016/j.bmcl.2012.07.029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis, molecular modeling and biological evaluation of substituted deoxybenzoins and optimized dihydrostilbenes are reported. Preliminary structure-activity relationship data were elucidated and lead compounds suitable for further optimization were discovered. Dihydrostilbene 7 is a particularly potent inhibitor (IC50 = 8.44 mu M, more potent than kojic acid). (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：5523 / 5526

页数：4

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