Augmenting Mitofusin-2 in Females With Pulmonary Arterial Hypertension Increases Mitochondrial Fusion, Reduces Smooth Muscle Cell Hyperproliferation and Regresses Experimental Disease

被引：0

作者：

Ryan, John J. ^{[1
]}

Marsboom, Glenn ^{[1
]}

Fang, Yong Hu ^{[1
]}

Toth, Peter T. ^{[1
]}

Marrow, Erik ^{[1
]}

Luo, Nancy ^{[1
]}

Piao, Lin ^{[1
]}

Hong, Zhigang ^{[1
]}

Zhang, Hannah ^{[1
]}

Haney, Chad ^{[1
]}

Chen, Chin-Tu ^{[1
]}

Sharp, Willard ^{[1
]}

Archer, Stephen ^{[1
]}

机构：

[1] Univ Chicago, Chicago, IL 60637 USA

来源：

CIRCULATION | 2012年 / 126卷 / 21期

关键词：

Mitochondria; Pulmonary circulation; Gene expression; Gene therapy;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

12688

引用

页数：2

共 44 条

[21] Expression of SMURF1 is Increased in Patients With Pulmonary Arterial Hypertension and SiRNA Inhibition of SMURF1 Reduces Pulmonary Artery Smooth Muscle Cell Proliferation
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[22] NMDA receptor crosstalk with PDGFR-β and BMPR2 is involved in smooth muscle cell proliferation in pulmonary arterial hypertension
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[23] Mammalian Target of Rapamycin Complex 2 ( mTORC2) Coordinates Pulmonary Artery Smooth Muscle Cell Metabolism, Proliferation, and Survival in Pulmonary Arterial Hypertension
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[24] PBI-4050 Reduces Angio-proliferative Pulmonary Arterial Hypertension: Decreased Human Pulmonary Artery Smooth Muscle Cell Proliferation and Microvascular Endothelial Cell Endoplasmic Reticulum Stress
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[25] Endothelin-Bone morphogenetic protein type 2 receptor interaction induces pulmonary artery smooth muscle cell hyperplasia in pulmonary arterial hypertension
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[26] HNRNPA2B1: RNA-Binding Protein That Orchestrates Smooth Muscle Cell Phenotype in Pulmonary Arterial Hypertension
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[27] Hnrnpa2b1 An Rna-binding Protein That Orchestrates Smooth Muscle Cell Phenotype In Pulmonary Arterial Hypertension
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[28] Dynamin-Related Protein 1 (DRP1)-Mediated Mitochondrial Fission Promotes Smooth Muscle Cell Hyperproliferation in Human and Experimental Pulmonary Hypertension Which Can be Therapeutically Targeted by the Fission Inhibitor MDIVI-1
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[29] Plasminogen activator Inhibitor-2 inhibits pulmonary arterial smooth muscle cell proliferation in pulmonary arterial hypertension via PI3K/Akt and ERK signaling
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[30] The Role of Mitochondrial Dynamics and Mitotic Fission in Regulating the Cell Cycle in Cancer and Pulmonary Arterial Hypertension: Implications for Dynamin-Related Protein 1 and Mitofusin2 in Hyperproliferative Diseases
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