Enhancement of tumorigenic, metastatic and in vitro invasive capacity of rat mammary tumor cells by transforming growth factor-β

被引：13
|
作者：
Nakata, D
Hamada, J
Ba, Y
Matsushita, K
Shibata, T
Hosokawa, M
Moriuchi, T
机构：
[1] Hokkaido Univ, Inst Med Genet, Div Canc Related Genes, Kita Ku, Sapporo, Hokkaido 0600815, Japan
[2] Hokkaido Univ, Inst Med Genet, Div Canc Pathobiol, Sapporo, Hokkaido 0600815, Japan
[3] Hlth Sci Univ Hokkaido, Dept Oral & Maxillofacial Surg 2, Tobetsu 0610293, Japan
来源：
CANCER LETTERS | 2002年 / 175卷 / 01期
基金：
日本科学技术振兴机构;
关键词：
transforming growth factor-beta; invasion; metastasis; adhesion; motility; CD44;
D O I：
10.1016/S0304-3835(01)00728-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We investigated the effects of transforming growth factor-beta (TGF-beta) on biological behavior of a weakly malignant rat mammary carcinoma ER-1 cell line. TGF-beta enhanced the tumorigenic and metastatic capacity of ER-1 cells and their in vitro invasiveness to rat mesothelial and endothelial cell. Further cell biological analysis indicated that the increased invasive and metastatic capacity of ER-1 cells by TGF-beta was due to the increase in cell motility and adhesion to the mesothelial and endothelial cell monolayers. Thus, it is suggested that TGF-beta acts on ER-1 cells as a progression-enhancing factor which stimulates their adhesive and motile activities. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：95 / 106
页数：12
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