Synthesis of Two Unnatural Oxygenated Aaptaminoids

被引：9

作者：

Abbiati, Giorgio ^{[1
]}

Doda, Arjana ^{[1
]}

Dell'Acqua, Monica ^{[1
]}

Pirovano, Valentina ^{[1
]}

Facoetti, Diego ^{[1
]}

Rizzato, Silvia ^{[2
]}

Rossi, Elisabetta ^{[1
]}

机构：

[1] Univ Milan, Dipartimento Sci Farmaceut, Sez Chim Gen & Organ A Marchesini, I-20133 Milan, Italy

[2] Univ Milan, Dipartimento Chim, I-20133 Milan, Italy

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 22期

关键词：

MODIFIED CURTIUS REACTION; ALPHA-BLOCKING ACTIVITY; CONVENIENT REAGENT; MARINE ALKALOIDS; DERIVATIVES; CYCLIZATION; ANALOGS; 4(1H)-QUINOLONES; ISOQUINOLINES; ISOAAPTAMINE;

D O I：

10.1021/jo3020598

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two unprecedented oxygenated aaptaminoids have been synthesized starting from cheap and easily available 2,3-dihydroxybenzoic acid with the satisfactory overall yields of 31% and 34%. The key step of the procedure is the divergent thermic 5-exodig vs base-promoted 6-endodig cyclization of a 5-alkynylquinolinone derivative.

引用

页码：10461 / 10467

页数：7

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