Can needle-free administration of vaccines become the norm in global immunization?

被引：120
|
作者：
Levine, Myron M. [1 ]
机构：
[1] Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA
来源：
NATURE MEDICINE | 2003年 / 9卷 / 01期
关键词：
D O I：
10.1038/nm0103-99
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
If vaccines could be administered without needles and syringes ('sharps'), immunization practice would become safer, more accepted and more suitable for mass use. The author explores the status of technologies that could achieve this aim and the barriers that must be overcome for their implementation.
引用
收藏
页码：99 / 103
页数：5
相关论文
共 50 条
  • [21] New Horizons in the Development of Novel Needle-Free Immunization Strategies to Increase Vaccination Efficacy
    Schulze, Kai
    Ebensen, Thomas
    Riese, Peggy
    Prochnow, Blair
    Lehr, Claus-Michael
    Guzman, Carlos A.
    HOW TO OVERCOME THE ANTIBIOTIC CRISIS: FACTS, CHALLENGES, TECHNOLOGIES AND FUTURE PERSPECTIVES, 2016, 398 : 207 - 234
  • [22] Transcutaneous immunization with heat-labile enterotoxin: development of a needle-free vaccine patch
    Glenn, Gregory M.
    Flyer, David C.
    Ellingsworth, Larry R.
    Frech, Sarah A.
    Frerichs, David M.
    Seid, Robert C., Jr.
    Yu, Jianmei
    EXPERT REVIEW OF VACCINES, 2007, 6 (05) : 809 - 819
  • [23] Demonstration of efficacy in pigs of Mycoplasma hyopneumoniae experimental vaccines by an innovative needle-free route
    Charreyre, C
    Milward, F
    Nordgren, R
    Royer, G
    36th Annual Meeting of the American Association of Swine Veterinarians, Proceedings, 2005, : 113 - 115
  • [24] The penetration of a soft solid by a liquid jet, with application to the administration of a needle-free injection
    Shergold, Oliver A.
    Fleck, Norman A.
    King, Toby S.
    JOURNAL OF BIOMECHANICS, 2006, 39 (14) : 2593 - 2602
  • [25] The effect of needle-free administration of local anesthetic on the behavior and physiology of castrated pigs
    Sutherland, Mhairi A.
    Backus, Brittany L.
    Brooks, Tiffanie A.
    McGlone, John J.
    JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH, 2017, 21 : 71 - 76
  • [26] Pharmacokinetics of nemifitide in healthy volunteers following subcutaneous administration by standard needle or needle-free (Bioject) injection
    Nicolau, G
    Feighner, JP
    Stout, R
    Hlavka, J
    Gutierez, M
    Carillo, N
    Freed, J
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2004, 7 : S174 - S174
  • [27] A needle-free approach for topical immunization:: Antigen delivery via vesicular carrier system(s)
    Mahor, Sunil
    Gupta, Prem N.
    Rawat, Amit
    Vyas, Suresh P.
    CURRENT MEDICINAL CHEMISTRY, 2007, 14 (27) : 2898 - 2910
  • [28] Enhancement of the immune response in rabbits to a malaria DNA vaccine by immunization with a needle-free jet device
    Aguiar, JC
    Hedstrom, RC
    Rogers, WO
    Charoenvit, Y
    Sacci, JB
    Lanar, DE
    Majam, VF
    Stout, RR
    Hoffman, SL
    VACCINE, 2001, 20 (1-2) : 275 - 280
  • [29] Induction of cytotoxic T-lymphocytes by electroporation-enhanced needle-free skin immunization
    Zhao, YL
    Murthy, SN
    Manjili, MH
    Guan, LJ
    Sen, A
    Hui, SW
    VACCINE, 2006, 24 (09) : 1282 - 1290
  • [30] Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice
    Dexiang Chen
    Ryan L. Endres
    Cherie A. Erickson
    Kathleen F. Weis
    Martha W. McGregor
    Yoshihiro Kawaoka
    Lendon G. Payne
    Nature Medicine, 2000, 6 : 1187 - 1190
12345