Recent progress in structure-based anti-influenza drug design

被引：69

作者：

Du, Juan ^{[1
,3
]}

Cross, Timothy A. ^{[2
,3
,4
]}

Zhou, Huan-Xiang ^{[1
,3
]}

机构：

[1] Florida State Univ, Dept Phys, Tallahassee, FL 32306 USA

[2] Florida State Univ, Dept Chem & Biochem, Tallahassee, FL 32306 USA

[3] Florida State Univ, Inst Mol Biophys, Tallahassee, FL 32306 USA

[4] Natl High Magnet Field Lab, Tallahassee, FL 32310 USA

来源：

DRUG DISCOVERY TODAY | 2012年 / 17卷 / 19-20期

基金：

美国国家卫生研究院;

关键词：

INFLUENZA-A VIRUS; M2 PROTON CHANNEL; RECEPTOR-BINDING PROPERTIES; NEURAMINIDASE INHIBITORS; SIALIC-ACID; MATRIX PROTEIN; HIGHLY POTENT; ION-CHANNEL; RNA-BINDING; M1; PROTEIN;

D O I：

10.1016/j.drudis.2012.06.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Seasonal and pandemic influenza have caused high morbidity and mortality worldwide. Recent emergence of influenza A H5N1 and H1N1 strains has heightened concern, especially as a result of their drug resistance. The life cycle of influenza viruses has been well studied and nearly all the viral proteins are becoming potential therapeutic targets. In this review, we present an overview of recent progress in structure-based anti-influenza drug design, paying close attention to the increasing role of computation and strategies for overcoming drug resistance.

引用

页码：1111 / 1120

页数：10

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