Recent progress in structure-based anti-influenza drug design

被引：69

作者：

Du, Juan ^{[1
,3
]}

Cross, Timothy A. ^{[2
,3
,4
]}

Zhou, Huan-Xiang ^{[1
,3
]}

机构：

[1] Florida State Univ, Dept Phys, Tallahassee, FL 32306 USA

[2] Florida State Univ, Dept Chem & Biochem, Tallahassee, FL 32306 USA

[3] Florida State Univ, Inst Mol Biophys, Tallahassee, FL 32306 USA

[4] Natl High Magnet Field Lab, Tallahassee, FL 32310 USA

来源：

DRUG DISCOVERY TODAY | 2012年 / 17卷 / 19-20期

基金：

美国国家卫生研究院;

关键词：

INFLUENZA-A VIRUS; M2 PROTON CHANNEL; RECEPTOR-BINDING PROPERTIES; NEURAMINIDASE INHIBITORS; SIALIC-ACID; MATRIX PROTEIN; HIGHLY POTENT; ION-CHANNEL; RNA-BINDING; M1; PROTEIN;

D O I：

10.1016/j.drudis.2012.06.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Seasonal and pandemic influenza have caused high morbidity and mortality worldwide. Recent emergence of influenza A H5N1 and H1N1 strains has heightened concern, especially as a result of their drug resistance. The life cycle of influenza viruses has been well studied and nearly all the viral proteins are becoming potential therapeutic targets. In this review, we present an overview of recent progress in structure-based anti-influenza drug design, paying close attention to the increasing role of computation and strategies for overcoming drug resistance.

引用

页码：1111 / 1120

页数：10

共 50 条

[1] Recent Advances in the Structure-Based Design of Neuraminidase Inhibitors as Anti-influenza Agents
Shan, Yuanyuan
Ma, Ying
Wang, Maoyi
Dong, Yalin
[J]. CURRENT MEDICINAL CHEMISTRY, 2012, 19 (34) : 5885 - 5894
[2] Recent Progress in Anti-Influenza Chemotherapy
Shigeta, Shiro
[J]. DRUGS IN R&D, 1999, 2 (03) : 153 - 164
[3] Recent Progress in Anti-Influenza Chemotherapy
Shiro Shigeta
[J]. Drugs in R & D, 1999, 2 : 153 - 164
[4] Progress in structure-based drug design against influenza A virus
Du, Qi-Shi
Wei, Hang
Huang, Ri-Bo
Chou, Kuo-Chen
[J]. EXPERT OPINION ON DRUG DISCOVERY, 2011, 6 (06) : 619 - 631
[5] PROGRESS IN ANTI-HIV STRUCTURE-BASED DRUG DESIGN
GAIT, MJ
KARN, J
[J]. TRENDS IN BIOTECHNOLOGY, 1995, 13 (10) : 430 - 438
[6] Structure-based discovery of anti-influenza virus A compounds among medicines
Fukuoka, Mayuko
Minakuchi, Moeko
Kawaguchi, Atsushi
Nagata, Kyosuke
Kamatari, Yuji O.
Kuwata, Kazuo
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2012, 1820 (02): : 90 - 95
[7] Recent developments in structure-based drug design
Gerhard Klebe
[J]. Journal of Molecular Medicine, 2000, 78 : 269 - 281
[8] Recent advances in structure-based drug design
Sherman, Woody
[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 239
[9] Recent developments in structure-based drug design
Klebe, G
[J]. JOURNAL OF MOLECULAR MEDICINE-JMM, 2000, 78 (05): : 269 - 281
[10] Recent Progress in the Discovery of Neuraminidase Inhibitors as Anti-influenza Agents
Rahim, Aisyah Saad Abdul
von Itzstein, Mark
[J]. ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 48, 2013, 48 : 249 - 263

← 1 2 3 4 5 →