Simulation of platelet deposition in disturbed flow

被引：0

作者：

Sorensen, EN ^{[1
]}

Burgreen, GW ^{[1
]}

Wagner, WR ^{[1
]}

Antaki, JF ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA 15261 USA

来源：

SECOND JOINT EMBS-BMES CONFERENCE 2002, VOLS 1-3, CONFERENCE PROCEEDINGS: BIOENGINEERING - INTEGRATIVE METHODOLOGIES, NEW TECHNOLOGIES | 2002年

关键词：

platelets; thrombosis; computational fluid dynamics; mathematical modeling;

D O I：

暂无

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

We have developed a two-dimensional computational model of platelet-mediated biomaterial thrombosis. When applied to plane Poiseuille flow over collagen, it showed very good agreement with experimental results. Here, we attempt to simulate platelet deposition onto collagen in the presence of disturbed flow in a tubular expansion. At 0% hematocrit, good agreement with experiments is obtained for the recirculation zone, but not for the fully-developed downstream zone. At 20% hematocrit, poor agreement is observed unless the platelet-surface reaction coefficients are altered. In both cases, it appears the deficiencies are due to incomplete modeling of platelet transport mechanisms.

引用

页码：390 / 391

页数：2

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