Evaluation of humoral immune response in adaptive immunity in ALS patients during disease progression

被引：25

作者：

Saleh, Islam A. ^{[1
]}

Zesiewicz, Theresa ^{[6
]}

Xie, Yong ^{[1
]}

Sullivan, Kelly L. ^{[6
]}

Miller, Amber M. ^{[6
]}

Kuzmin-Nichols, Nicole ^{[7
]}

Sanberg, Paul R. ^{[1
,2
,3
,4
,5
]}

Garbuzova-Davis, Svitlana ^{[1
,2
,3
,4
]}

机构：

[1] Univ S Florida, Ctr Excellence Aging & Brain Repair, Coll Med, Tampa, FL 33612 USA

[2] Univ S Florida, Dept Neurosurg, Coll Med, Tampa, FL 33612 USA

[3] Univ S Florida, Dept Mol Pharmacol & Physiol, Coll Med, Tampa, FL 33612 USA

[4] Univ S Florida, Dept Pathol & Cell Biol, Coll Med, Tampa, FL 33612 USA

[5] Univ S Florida, Dept Psychiat, Coll Med, Tampa, FL 33612 USA

[6] Univ S Florida, Dept Neurol, Coll Med, Tampa, FL 33612 USA

[7] Saneron CCEL Therapeut Inc, Tampa, FL 33612 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 215卷 / 1-2期

关键词：

Amyotrophic lateral sclerosis; Humoral immune response; Circulating immune complexes; IgG; IgM; AMYOTROPHIC-LATERAL-SCLEROSIS; SUPEROXIDE-DISMUTASE GENE; SPINAL-CORD; POLYETHYLENE-GLYCOL; MOTOR CORTEX; T-CELLS; COMPLEXES; SYSTEM; IGG; REACTIVITY;

D O I：

10.1016/j.jneuroim.2009.07.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In ALS, evidence suggests immune reactions in disease pathogenesis. Although immunological changes point to adaptive immune response, whether humoral or cellular response dominates during disease course is unknown. The study aim was to evaluate humoral immune response in ALS patients during disease progression. Circulating immune complexes (CICs), IgG, and IgM in sera of ALS patients and matching controls were evaluated after each of two visits. Results showed significantly elevated ClCs and IgG in ALS patient sera. CICs decreased to control levels at the second visit, yet IgG remained higher than controls. Serum IgM was within normal range. Results suggest a humoral immune response initiating adaptive immunity in ALS, however, cellular immune response needs verification. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：96 / 101

页数：6

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