Impact of G protein-coupled receptor heteromers in endocrine systems

被引：13

作者：

Jonas, K. C. ^{[1
]}

Hanyaloglu, A. C. ^{[2
]}

机构：

[1] St Georges Univ London, Ctr Med & Biomed Educ, Cell Biol & Genet Res Ctr, London, England

[2] Imperial Coll London, Inst Reprod & Dev Biol, Dept Surg & Cancet, London, England

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2017年 / 449卷 / 0C期

基金：

英国生物技术与生命科学研究理事会;

关键词：

GPCR; Dimer; Oligomer; Signaling; Heteromer; RESONANCE ENERGY-TRANSFER; SINGLE-MOLECULE ANALYSIS; TIME-RESOLVED FRET; LUTEINIZING-HORMONE; HUMAN GRANULOSA; HETERODIMERIZATION; LUTROPIN; GHRELIN; REVEAL; CELLS;

D O I：

10.1016/j.mce.2017.01.030

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The fine-tuning of endocrine homeostasis is regulated by dynamic receptor mediated processes. The superfamily of G protein-coupled receptors (GPCRs) have diverse roles in the modulation of all endocrine axes, thus understanding the mechanisms underpinning their functionality is paramount for treatment of endocrinopathies. Evidence over the last 20 years has highlighted homo and heteromerization as a key mode of mediating GPCR functional diversity. This review will discuss the concept of GPCR heteromerization and its relevance to endocrine function, detailing in vitro and in vivo evidence, and exploring current and potential pharmacological strategies for specific targeting of GPCR heteromers in endocrine heath and disease. Crown Copyright (C) 2017 Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：21 / 27

页数：7

共 50 条

[31] Mutations in G proteins and G protein-coupled receptors in endocrine disease
Spiegel, AM
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (07): : 2434 - 2442
[32] Understanding the Added Value of G-Protein-Coupled Receptor Heteromers
Franco, Nuria
Franco, Rafael
SCIENTIFICA, 2014, 2014
[33] G Protein-Coupled Receptor Resensitization Paradigms
Gupta, Manveen K.
Mohan, Maradumane L.
Prasad, Sathyamangla V. Naga
G PROTEIN-COUPLED RECEPTORS: EMERGING PARADIGMS IN ACTIVATION, SIGNALING AND REGULATION, PT B, 2018, 339 : 63 - 91
[34] G protein-coupled receptors and G proteins in endocrine disease - Preface
Ulloa-Aguirre, A
Conn, PM
ARCHIVES OF MEDICAL RESEARCH, 1999, 30 (06): : 419 - 419
[35] G-protein-coupled receptor heteromers:: function and ligand pharmacology
Franco, R.
Casado, V.
Cortes, A.
Mallol, J.
Ciruela, F.
Ferre, S.
Lluis, C.
Canela, Ei
BRITISH JOURNAL OF PHARMACOLOGY, 2008, 153 : S90 - S98
[36] On the G Protein-Coupled Receptor Neuromodulation of the Claustrum
Dasiel O. Borroto-Escuela
Kjell Fuxe
Neurochemical Research, 2020, 45 : 5 - 15
[37] Imaging G protein-coupled receptor islands
Park, PSH
Palczewski, K
NATURE CHEMICAL BIOLOGY, 2005, 1 (04) : 184 - 185
[38] G protein-coupled receptor (GPCR) pharmacogenomics
Thompson, Miles D.
Reiner-Link, David
Berghella, Alessandro
Rana, Brinda K.
Rovati, G. Enrico
Capra, Valerie
Gorvin, Caroline M.
Hauser, Alexander S.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2024, 61 (08) : 641 - 684
[39] Characterization of G protein-coupled receptor kinases
Pronin, AN
Loudon, RP
Benovic, JL
G PROTEIN PATHWAYS, PT A, RECEPTORS, 2002, 343 : 547 - 559
[40] Photoactivation of G protein-coupled receptor rhodopsin
Yan, Elsa C. Y.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2007, 24 (06): : 730 - 730

← 1 2 3 4 5 →