The FTO, PNPLA3 and TM6SF2 Gene Polymorphisms and Genetic Predisposition to NAFLD in Yakut Population

被引：0
|
作者：
Diakonova, Aleksandra T. [1 ]
Kurtanov, Khariton A. [1 ]
Pavlova, Nadezhda I. [1 ]
Aleksandrova, Tuyara N. [1 ]
机构：
[1] Yakut Sci Ctr Complex Med Problems, Yakutsk, Russia
来源：
INTERNATIONAL JOURNAL OF BIOMEDICINE | 2021年 / 11卷 / 01期
关键词：
nonalcoholic fatty liver disease; single nucleotide polymorphism; genome-wide association study; Yakuts;
D O I：
10.21103/Article11(1)_OA16
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The aim of our research was to study the distribution of alleles and genotypes of the FTO rs9939609 SNP, the PNPLA3 rs738409 SNP, and the TM6SF2 rs58542926 SNP in the Yakut population. Methods and Results: A total of 85 DNA samples from the population were tested. An analysis of the frequency distribution of alleles and genotypes of the FTO rs9939609 SNP in the study group did not reveal significant differences. An analysis of the frequency distribution of alleles and genotypes of the PNPLA3 rs738409 SNP revealed that in men and women the G allele and the homozygous GG genotype prevailed. The results of the analysis of the frequency distribution of alleles and genotypes of the TM6SF2 rs58542926 SNP showed the predominance of individuals with the C allele (89% in men and 90% in women) with statistical significance in women. Conclusion: The further studies with a larger sample size are required to detect the features of the distribution of alleles and genotypes of the FTO rs9939609 SNP and the TM6SF2 rs58542926 SNP in that population.
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页码：92 / 95
页数：4
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