Arsenic-Containing Phosphatidylcholines: A New Group of Arsenolipids Discovered in Herring Caviar

被引：45
|
作者：
Viczek, Sandra A. [1 ]
Jensen, Kenneth B. [1 ]
Francesconi, Kevin A. [1 ]
机构：
[1] Graz Univ, NAWI Graz, Inst Chem Analyt Chem, Univ Pl 1, A-8010 Graz, Austria
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 17期
基金：
奥地利科学基金会;
关键词：
arsenic; arsenolipids; phosphatidylcholines; phospholipids; VITRO TOXICOLOGICAL CHARACTERIZATION; CONTAINING FATTY-ACIDS; CONTAINING HYDROCARBONS; BROWN ALGA; FISH; OIL; IDENTIFICATION; FRAGMENTATION; SPECTROMETRY;
D O I：
10.1002/anie.201512031
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new group of arsenolipids based on cell-membrane phosphatidylcholines has been discovered in herring caviar (fish roe). A combination of HPLC with elemental and molecular mass spectrometry was used to identify five arsenic-containing phosphatidylcholines; the same technique applied to salmon caviar identified an arsenic-containing phosphatidylethanolamine. The arsenic group in these membrane lipids might impart particular properties to the molecules not displayed by their non-arsenic analogues. Additionally, the new compounds have human health implications according to recent results showing high cytotoxicity for some arsenolipids.
引用
收藏
页码：5259 / 5262
页数：4
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