Organocatalytic [4+2] cyclizations of para-quinone methide derivatives with isocyanates

被引：19

作者：

Cheng, Yu-Chun ^{[1
]}

Wang, Cong-Shuai ^{[1
]}

Li, Tian-Zhen ^{[1
]}

Gao, Feng ^{[1
]}

Jiao, Yinchun ^{[2
]}

Shi, Feng ^{[1
]}

机构：

[1] Jiangsu Normal Univ, Sch Chem & Mat Sci, Xuzhou 221116, Jiangsu, Peoples R China

[2] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 27期

关键词：

CATALYTIC 1,6-CONJUGATE ADDITION/AROMATIZATION; DIELS-ALDER REACTION; ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE CONSTRUCTION; COUMARIN DERIVATIVES; ACID; CYCLOADDITION; DIHYDROCOUMARINS; ALKYLATION; ANNULATION;

D O I：

10.1039/c9ob00918c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first [4 + 2] cyclizations of para-quinone methide derivatives with isocyanates have been established under the catalysis of Bronsted acids or Bronsted bases, which efficiently constructed benzoxazin-2-one frameworks in generally high yields (up to 95%). This reaction will not only enrich the research contents of para-quinone methide-involved cyclization reactions but also provide a useful method for constructing biologically important benzoxazin-2-one frameworks.

引用

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页码：6662 / 6670

页数：9

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