MicroRNA-133 mediates cardiac diseases: Mechanisms and clinical implications

被引：32
|
作者：
Liu, Yi [1 ]
Liang, Yan [1 ]
Zhang, Jin-fang [2 ]
Fu, Wei-ming [3 ]
机构：
[1] Guangdong Med Univ, Guangdong Key Lab Res & Dev Nat Drugs, Zhanjiang 524023, Guangdong, Peoples R China
[2] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Orthopaed & Traumatol, Shatin, Hong Kong, Peoples R China
[3] Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China
来源：
EXPERIMENTAL CELL RESEARCH | 2017年 / 354卷 / 02期
基金：
中国国家自然科学基金;
关键词：
MicroRNAs; Heart disease; Target genes; MiR-133; Cardiac hypertrophy; HUMAN HEART; ATRIAL-FIBRILLATION; GENE-EXPRESSION; NUCLEAR EXPORT; SKELETAL; CALCINEURIN; MIR-1; HYPERTROPHY; PROLIFERATION; RNAS;
D O I：
10.1016/j.yexcr.2017.03.037
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNAs (miRNAs) belong to the family of small non-coding RNAs that mediate gene expression by post transcriptional regulation. Increasing evidence have demonstrated that miR-133 is enriched in muscle tissues and myogenic cells, and its aberrant expression could induce the occurrence and development of cardiac disorders, such as cardiac hypertrophy, heart failure, etc. In this review, we summarized the regulatory roles of miR-133 in cardiac disorders and the underlying mechanisms, which suggest that miR-133 may be a potential diagnostic and therapeutic tool for cardiac disorders.
引用
收藏
页码：65 / 70
页数：6
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