Glycoconjugate Vaccines for Prevention of Haemophilus influenzae Type b Diseases

被引：11
|
作者：
Khatuntseva, E. A. [1 ]
Nifantiev, N. E. [1 ]
机构：
[1] Russian Acad Sci, Zelinsky Inst Organ Chem, Moscow 119991, Russia
来源：
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2021年 / 47卷 / 01期
基金：
俄罗斯科学基金会;
关键词：
glycoconjugate vaccines; conjugation; synthesis; poly-3-β -D-ribosyl-(1→ 1)-D-ribitol-5-phosphate; PRP; Haemophilus influenzae type b; Hib; POLYSACCHARIDE CONJUGATE VACCINES; PNEUMONIAE TYPE 14; CAPSULAR POLYSACCHARIDE; STREPTOCOCCUS-PNEUMONIAE; NEISSERIA-MENINGITIDIS; SERUM ANTIBODIES; ASPERGILLUS-FUMIGATUS; CELL-WALL; 1-CYANO-4-DIMETHYLAMINOPYRIDINIUM TETRAFLUOROBORATE; SOLUBLE POLYSACCHARIDES;
D O I：
10.1134/S1068162021010106
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review summarizes the experience in laboratory- and industrial-scale syntheses of glycoconjugate vaccines used for prevention of infectious diseases caused by Haemophilus influenzae type b bacteria based on the linear capsular polysaccharide poly-3-beta-D-ribosyl-(1 -> 1)-D-ribitol-5-phosphate (PRP) or related synthetic oligosaccharide ligands. The methods for preparation of related oligosaccharide derivatives and results of the studies evaluating effect of their length on immunogenic properties of the conjugates with protein carriers are overviewed.
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页码：26 / 52
页数：27
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