GENE, BRAIN, AND BEHAVIOR RELATIONSHIPS IN FRAGILE X SYNDROME: EVIDENCE FROM NEUROIMAGING STUDIES

被引:60
|
作者
Lightbody, Amy A. [1 ]
Reiss, Allan L. [1 ]
机构
[1] Stanford Univ, Ctr Interdisciplinary Brain Sci Res, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
关键词
fragile X syndrome; MRI; FMR1; behavior and intellectual disability; AUTISM SPECTRUM DISORDER; TURNER-SYNDROME; STATUS CATEGORIES; UNDERLYING FACE; POSTERIOR-FOSSA; WORKING-MEMORY; SOCIAL ANXIETY; YOUNG MALES; CHILDREN; FEMALES;
D O I
10.1002/ddrr.77
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Fragile X syndrome (FraX) remains the most common inherited cause of intellectual disability and provides a valuable model for studying gene-brain-behavior relationships. Over the past 15 years, structural and functional magnetic resonance imaging studies have emerged with the goal of better understanding the neural pathways contributing to the cognitive and behavioral outcomes seer in individuals with Frak Specifically, structural MRI studies have established and begun to refine the specific topography of neuroanatomical variation associated with Frak In addition, functional neuroimaging studies have begun to elucidate the neural underpinnings of many of the unique characteristics of FraX including difficulties with eye gaze, executive functioning, and behavioral inhibition. This review highlights studies with a focus on the relevant gene-brain-behavior connections observed in FraX. The relationship of brain regions and activation patterns to FMRP are discussed as well as the clinical cognitive and behavioral correlates of these neuroimaging findings. (C) 2009 Wiley-Liss, Inc. Dev Disabil Res Rev 2009;15:343-352.
引用
收藏
页码:343 / 352
页数:10
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