NOD1 and NOD2 in inflammatory and infectious diseases

被引：104

作者：

Trindade, Bruno C. ^{[1
]}

Chen, Grace Y. ^{[1
]}

机构：

[1] Univ Michigan, Dept Internal Med, Div Hematol & Oncol, 1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA

来源：

IMMUNOLOGICAL REVIEWS | 2020年 / 297卷 / 01期

基金：

美国国家卫生研究院; 美国食品与农业研究所;

关键词：

immunity; inflammation; innate; NOD1; NOD2; Nod-like receptor; NF-KAPPA-B; OLIGOMERIZATION DOMAIN 1; INNATE IMMUNE-RESPONSES; PEDIATRIC GRANULOMATOUS ARTHRITIS; INTESTINAL EPITHELIAL-CELLS; OUTER-MEMBRANE VESICLES; EARLY-ONSET SARCOIDOSIS; ENDOPLASMIC-RETICULUM STRESS; TRANSPORTS MURAMYL DIPEPTIDE; ENVIRONMENTAL RISK-FACTORS;

D O I：

10.1111/imr.12902

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It has been long recognized that NOD1 and NOD2 are critical players in the host immune response, primarily by their sensing bacterial peptidoglycan-conserved motifs. Significant advances have been made from efforts that characterize their upstream activators, assembly of signaling complexes, and activation of downstream signaling pathways. Disruption in NOD1 and NOD2 signaling has also been associated with impaired host defense and resistance to the development of inflammatory diseases. In this review, we will describe how NOD1 and NOD2 sense microbes and cellular stress to regulate host responses that can affect disease pathogenesis and outcomes.

引用

页码：139 / 161

页数：23

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