Effect of laparoscopic Nissen fundoplication on symptoms and gastric myoelectric activity in gastroesophageal reflux disease

被引:2
|
作者
Chen, CL
Reif, ME
Orr, WC
机构
[1] Buddhist Tzu Chi Gen Hosp & Med Sch, Div Gastroenterol & Hepatol, Hualien, Taiwan
[2] Lynn Inst Healthcare Res, Oklahoma City, OK USA
关键词
gastric myoelectrical activity; gastroesophageal reflux disease; fundoplication;
D O I
10.1097/01.mcg.0000210097.51747.4b
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: Laparoscopic Nissen fundoplication is an effective treatment for gastroesophageal reflux disease (GERD). The aim of this study was to determine whether laparoscopic fundoplication alters gastric myoelectric activity. Change of digestive symptoms was also assessed. Methods: Sixteen patients with GERD (2 males, 14 females, mean age: 53 years) undergoing a laparoscopic fundoplication participated. Electrogastrography (EGG) was assessed before and after the subject ingested water until full (water load). Symptoms of upper abdominal discomfort, early satiety, postprandial abdominal distension, nausea, vomiting, and anorexia were recorded. At a 2-month postoperative follow-up, preoperative tests were repeated. Results: The EGG was abnormal in 11 of 16 patients (69%) preoperatively and 6 of 16 patients (38%) postoperatively. The EGG changed from abnormal to normal in 5 of 16 patients (31%). The percentage of power at 3 cpm increased significantly during the fasting state postoperatively (29.9% vs. 21.2%, P < 0.05). There was a significant improvement in epigastric pain (P < 0.001), early satiety (P < 0.01), and postprandial fullness (P < 0.001). Conclusions: Increased presence of normal 3 cpm activity is the predominant effect of fundoplication on gastric myoelectric activity. Dyspeptic symptoms are also significantly improved postoperatively.
引用
收藏
页码:301 / 305
页数:5
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