Hollow Prussian Blue Nanozymes Drive Neuroprotection against Ischemic Stroke via Attenuating Oxidative Stress, Counteracting Inflammation, and Suppressing Cell Apoptosis

被引：230

作者：

Zhang, Kai ^{[1
,2
]}

Tu, Mengjiao ^{[1
,2
]}

Gao, Wei ^{[2
,3
]}

Cai, Xiaojun ^{[2
,3
]}

Song, Fahuan ^{[1
,2
]}

Chen, Zheng ^{[5
]}

Zhang, Qian ^{[6
]}

Wang, Jing ^{[1
,2
]}

Jin, Chentao ^{[1
,2
]}

Shi, Jingjing ^{[1
,2
]}

Yang, Xiang ^{[1
,2
]}

Zhu, Yuankai ^{[1
,2
]}

Gu, Weizhong ^{[7
]}

Hu, Bing ^{[2
,3
]}

Zheng, Yuanyi ^{[2
,3
]}

Zhang, Hong ^{[1
,2
,4
]}

Tian, Mei ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Hosp 2, Sch Med, Dept Nucl Med, Hangzhou 310009, Zhejiang, Peoples R China

[2] Zhejiang Univ, Hosp 2, Sch Med, PET CT Ctr, Hangzhou 310009, Zhejiang, Peoples R China

[3] Shanghai Jiao Tong Univ Affiliated, Peoples Hosp 6, Shanghai Inst Ultrasound Med, Shanghai 200233, Peoples R China

[4] Shanxi Med Univ, Taiyuan 030001, Shanxi, Peoples R China

[5] Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Neurosurg, Shanghai 200082, Peoples R China

[6] Tongji Univ, Peoples Hosp 10, Dept Oncol, Shanghai 200072, Peoples R China

[7] Zhejiang Univ, Childrens Hosp, Sch Med, Dept Pathol, Hangzhou 310051, Zhejiang, Peoples R China

来源：

NANO LETTERS | 2019年 / 19卷 / 05期

基金：

中国国家自然科学基金;

关键词：

ischemic stroke; hollow Prussian blue; neuroprotection; nanozyme; reactive oxygen and nitrogen species; TISSUE-PLASMINOGEN ACTIVATOR; SHSY5Y NEUROBLASTOMA-CELLS; NF-KAPPA-B; CEREBRAL-ISCHEMIA; THERANOSTIC AGENT; OXYGEN; BRAIN; NANOPARTICLES; GENERATION; ANTIOXIDANT;

D O I：

10.1021/acs.nanolett.8b04729

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ischemic stroke is a devastating disease and one of the leading causes of mortality worldwide. Overproduction of reactive oxygen and nitrogen species (RONS) following ischemic insult is known as a key factor in exacerbating brain damage. Thus, RONS scavengers that can block excessive production of RONS have great therapeutic potential. Herein, we propose an efficient treatment strategy in which an artificial nanozyme with multienzyme activity drives neuroprotection against ischemic stroke primarily by scavenging RONS. Specifically, through a facile, Bi3+-assisted, template-free synthetic strategy, we developed hollow Prussian blue nanozymes (HPBZs) with multienzyme activity to scavenge RONS in a rat model of ischemic stroke. The comprehensive characteristics of HPBZs against RONS were explored. Apart from attenuating oxidative stress, HPBZs also suppressed apoptosis and counteracted inflammation both in vitro and in vivo, thereby contributing to increased brain tolerance of ischemic injury with minimal side effects. This study provides a proof of concept for a novel class of neuroprotective nanoagents that might be beneficial for treatment of ischemic stroke and other RONS-related disorders.

引用

页码：2812 / 2823

页数：12