A new chiral dipyridylphosphine ligand Xyl-P-Phos and its application in the Ru-catalyzed asymmetric hydrogenation of β-ketoesters

被引：63

作者：

Wu, J

Chen, H

Kwok, WH

Lam, KH

Zhou, ZY

Yeung, CH ^{[1
]}

Chan, ASC

机构：

[1] Hong Kong Polytech Univ, Inst Mol Technol Drug Discovery & Synth, Open Lab Chirotechnol, Hong Kong, Hong Kong, Peoples R China

[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 08期

关键词：

asymmetric hydrogenation; dipyridylphosphine ligands; ruthenium complex; beta-ketoeter;

D O I：

10.1016/S0040-4039(02)00062-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new chiral dipyridylphosphine ligand Xyl-P-Phos has been synthesized and the structure of (S)-Xyl-P-Phos oxide has been characterized by single crystal X-ray diffraction. The ruthenium complex of this ligand Ru(R-Xyl-P-Phos)(C6H6)Cl-2. has been found to be a highly active, enantioselective and air-stable catalyst for the asymmetric hydrogenation of beta-ketoesters and shows good potential for industrial applications. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：1539 / 1543

页数：5

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