A new chiral dipyridylphosphine ligand Xyl-P-Phos and its application in the Ru-catalyzed asymmetric hydrogenation of β-ketoesters

被引：63
|
作者：
Wu, J
Chen, H
Kwok, WH
Lam, KH
Zhou, ZY
Yeung, CH [1 ]
Chan, ASC
机构：
[1] Hong Kong Polytech Univ, Inst Mol Technol Drug Discovery & Synth, Open Lab Chirotechnol, Hong Kong, Hong Kong, Peoples R China
[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 08期
关键词：
asymmetric hydrogenation; dipyridylphosphine ligands; ruthenium complex; beta-ketoeter;
D O I：
10.1016/S0040-4039(02)00062-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new chiral dipyridylphosphine ligand Xyl-P-Phos has been synthesized and the structure of (S)-Xyl-P-Phos oxide has been characterized by single crystal X-ray diffraction. The ruthenium complex of this ligand Ru(R-Xyl-P-Phos)(C6H6)Cl-2. has been found to be a highly active, enantioselective and air-stable catalyst for the asymmetric hydrogenation of beta-ketoesters and shows good potential for industrial applications. (C) 2002 Published by Elsevier Science Ltd.
引用
收藏
页码：1539 / 1543
页数：5
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