Efficacy of Fluconazole and Nystatin in the Treatment of Vaginal Candida Species

被引：27

作者：

Rodrigues Martins, Helen Priscila ^{[1
]}

da Silva, Mariana Clivati ^{[1
]}

Farias Paiva, Luciene Cassia ^{[1
]}

Estivalet Svidzinski, Terezinha Inez ^{[2
]}

Lopes Consolaro, Marcia Edilaine ^{[1
]}

机构：

[1] Univ Estadual Maringa, Dept Clin Anal & Biomed, Clin Cytol Lab, Maringa, Parana, Brazil

[2] Univ Estadual Maringa, Dept Clin Anal & Biomed, Med Mycol Lab, Maringa, Parana, Brazil

来源：

ACTA DERMATO-VENEREOLOGICA | 2012年 / 92卷 / 01期

关键词：

efficacy; fluconazole; nystatin; treatment; vaginal Candida spp; ANTIFUNGAL; YEASTS; WOMEN;

D O I：

10.2340/00015555-1194

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The aim of this study was to determine and compare the efficacy of treatment with fluconazole and nystatin in Brazilian women with vaginal Candida. In a population of 932 women, vaginal cultures were performed for yeasts, whether or not the women showed signs and symptoms of vulvovaginal candidiasis. Yeasts were isolated from 12.2% of the women (114/932): 53.2% of the yeasts were Candida albicans, 27.0% C. glabrata, 13.5% C. tropicalis and 6.3% C. parapsilosis. Treatment was carried out with both drugs. The overall mean cure rates with fluconazole (87.0%) and nystatin (74.0%) were similar; among women with non-albicans, the cure rate with fluconazole was 100%, whereas that with nystatin was 44.4%. The cure rate for women with C. albicans was high with both fluconazole and nystatin; however, for those with non-albicans species the cure rate was excellent with fluconazole and very low with nystatin, differing from the majority of in vitro studies.

引用

页码：78 / 82

页数：5

共 50 条

[21] THE USE OF NYSTATIN IN THE TREATMENT OF VAGINAL CANDIDIASIS IN PREGNANCY
KAYSER, HL
EISENBERG, GM
SHAPIRO, J
FLIPPIN, HF
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1957, 74 (01) : 167 - 169
[22] Fluconazole treatment of candidal infections caused by non-albicans Candida species
vantWout, JW
[J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1996, 15 (03) : 238 - 242
[23] Evaluation of the susceptibility of pathogenic Candida species to fluconazole
Bille, J
Glauser, MP
[J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1997, 16 (12) : 924 - 928
[24] Fluconazole resistance in Candida species: a current perspective
Berkow, Elizabeth L.
Lockhart, Shawn R.
[J]. INFECTION AND DRUG RESISTANCE, 2017, 10 : 237 - 245
[25] Activated lactoferrin and fluconazole synergism against Candida albicans and Candida glabrata vaginal isolates
Naidu, AS
Fowler, RS
Martinez, C
Chen, J
Tulpinski, J
[J]. JOURNAL OF REPRODUCTIVE MEDICINE, 2004, 49 (10) : 800 - 807
[26] Candida norvegensis: A fluconazole-resistant species
Sandven, P
Nilsen, K
Digranes, A
Tjade, T
Lassen, J
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (06) : 1375 - 1376
[27] SUCCESSFUL TREATMENT OF CANDIDA PERITONITIS WITH FLUCONAZOLE
AGUADO, JM
HIDALGO, M
RIDRIGUEZTUDELA, JL
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1994, 34 (05) : 847 - 847
[28] TREATMENT OF CANDIDA EPIDIDIMOORCHITIS WITH ORAL FLUCONAZOLE
GORDON, DL
MADDERN, J
[J]. MEDICAL JOURNAL OF AUSTRALIA, 1992, 156 (10) : 744 - 744
[29] DOUBLE-BLIND COMPARISON OF CLOTRIMAZOLE AND NYSTATIN VAGINAL TABLETS IN CANDIDA VAGINITIS
MARKS, HJ
[J]. POSTGRADUATE MEDICAL JOURNAL, 1974, 50 : 105 - 107
[30] Fluconazole susceptibility and ERG11 gene expression in vaginal candida species isolated from lagos Nigeria
Pam, Victoria K.
Akpan, Juliet U.
Oduyebo, Oyinlola O.
Nwaokorie, Francisca O.
Fowora, Muinah A.
Oladele, Rita O.
Ogunsola, Folasade T.
Smith, Stella I.
[J]. INTERNATIONAL JOURNAL OF MOLECULAR EPIDEMIOLOGY AND GENETICS, 2012, 3 (01): : 84 - 90

← 1 2 3 4 5 →