Efficacy of Fluconazole and Nystatin in the Treatment of Vaginal Candida Species

被引：27

作者：

Rodrigues Martins, Helen Priscila ^{[1
]}

da Silva, Mariana Clivati ^{[1
]}

Farias Paiva, Luciene Cassia ^{[1
]}

Estivalet Svidzinski, Terezinha Inez ^{[2
]}

Lopes Consolaro, Marcia Edilaine ^{[1
]}

机构：

[1] Univ Estadual Maringa, Dept Clin Anal & Biomed, Clin Cytol Lab, Maringa, Parana, Brazil

[2] Univ Estadual Maringa, Dept Clin Anal & Biomed, Med Mycol Lab, Maringa, Parana, Brazil

来源：

ACTA DERMATO-VENEREOLOGICA | 2012年 / 92卷 / 01期

关键词：

efficacy; fluconazole; nystatin; treatment; vaginal Candida spp; ANTIFUNGAL; YEASTS; WOMEN;

D O I：

10.2340/00015555-1194

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The aim of this study was to determine and compare the efficacy of treatment with fluconazole and nystatin in Brazilian women with vaginal Candida. In a population of 932 women, vaginal cultures were performed for yeasts, whether or not the women showed signs and symptoms of vulvovaginal candidiasis. Yeasts were isolated from 12.2% of the women (114/932): 53.2% of the yeasts were Candida albicans, 27.0% C. glabrata, 13.5% C. tropicalis and 6.3% C. parapsilosis. Treatment was carried out with both drugs. The overall mean cure rates with fluconazole (87.0%) and nystatin (74.0%) were similar; among women with non-albicans, the cure rate with fluconazole was 100%, whereas that with nystatin was 44.4%. The cure rate for women with C. albicans was high with both fluconazole and nystatin; however, for those with non-albicans species the cure rate was excellent with fluconazole and very low with nystatin, differing from the majority of in vitro studies.

引用

页码：78 / 82

页数：5

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