Evaluation of mismatch negativity as a marker for language impairment in autism spectrum disorder

被引:12
|
作者
Green, Heather L. [1 ,2 ]
Shuffrey, Lauren C. [1 ,3 ]
Levinson, Lisa [1 ]
Shen, Guannan [1 ,4 ]
Avery, Trey [1 ,5 ]
Wagner, Melissa Randazzo [1 ,6 ]
Sepulveda, Dayna Moya [1 ,7 ]
Garcia, Paula [1 ,8 ]
Maddox, Chaille [1 ]
Garcia, Felicidad [1 ,9 ]
Hassan, Sommer [1 ,10 ]
Froud, Karen [1 ]
机构
[1] Columbia Univ, Teachers Coll, Dept Biobehav Sci, 1155 Thorndike Hall,525 W 120th St, New York, NY 10027 USA
[2] Childrens Hosp Philadelphia, Lurie Family Fdn MEG Imaging Ctr, Dept Radiol, 3401 Civ Ctr Blvd, Philadelphia, PA 19104 USA
[3] Columbia Univ, Div Dev Neurosci, Med Ctr, 3960 Broadway, New York, NY 10032 USA
[4] Temple Univ, Dept Psychotherapy, 1301 Cecil B Moore Ave, Philadelphia, PA 19122 USA
[5] Yale Univ, Haskins Labs, 300 George St, New Haven, CT 06511 USA
[6] Adelphi Univ, Dept Commun Sci & Disorders, One South Ave, Garden City, NY 11530 USA
[7] Pontificia Univ Catolica Chile, Villarrica 4930000, La Araucania Re, Chile
[8] Univ Los Andes, Calle 18 A 0-19 Este, Casita Rosada, Colombia
[9] Temple Univ, Dept Commun Sci & Disorders, 1301 Cecil B Moore Ave, Philadelphia, PA 19122 USA
[10] Univ Dist Columbia, 4200 Connecticut Ave NW, Washington, DC 20008 USA
关键词
ASD; Language; Electroencephalography; Electrophysiology; Mismatch negativity; Biomarker; EVENT-RELATED POTENTIALS; EARLY INFANTILE-AUTISM; NON-SPEECH SOUNDS; PLANUM TEMPORALE; CORPUS-CALLOSUM; FRONTAL-CORTEX; YOUNG-CHILDREN; BRAIN; CONNECTIVITY; PERCEPTION;
D O I
10.1016/j.jcomdis.2020.105997
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
Background: The identification of an early and objective marker of language impairment in autism spectrum disorder (ASD) has the potential to lead to earlier language intervention for affected children. The mismatch negativity (MMN), a passive auditory evoked potential, offers insight into the brain's ability to direct attention to novel sounds. Since exposure to speech is necessary for learning to map meaning onto phonemes, we predicted slower MMN responses to speech sounds would indicate presence of language impairment in ASD. Methods: We explored the relationship between MMN latency in children ages 5-10 with ASD plus language impairment (ASD + LI), ASD minus language impairment (ASD-LI), and typically developing children (TD) during an auditory oddball experiment presenting speech and pure tone sounds. Results: Contrary to our prediction, children with ASD + LI demonstrated decreased MMN latency in the left hemisphere in response to novel vowel sounds compared to children with ASD-LI and TD controls. Parent responses to the Sensory Experiences Questionnaire revealed that all participating individuals with ASD were hypersensitive to sounds. Conclusions: Our results lend support to the theory that some children with ASD + LI have increased connectivity in primary sensory cortices at the expense of connectivity to association areas of the brain. This may account for faster speech sound processing despite low language scores in these children. Future studies should focus on individuals with language impairment and hyper-or hyposensitivity to sounds.
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页数:15
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