SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NEW 2,5-DISUBSTITUTED 1,3,4-OXADIAZOLES

被引：0

作者：

Rajak, Harish ^{[1
]}

Gupta, Arun Kumar ^{[2
]}

Kharya, Murli Dhar

Mishra, Pradeep ^{[3
]}

机构：

[1] Guru Ghasidas Univ, SLT Inst Pharmaceut Sci, Bilaspur 495009, Chhattisgarh, India

[2] BPS Mahila Vishwavidyalaya, Khapur Kalan, Sonepat, India

[3] GLA Inst Pharmaceut Sci & Res, Mathura 281406, Uttar Pradesh, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2009年 / 19卷 / 01期

关键词：

DERIVATIVES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of new 2,5-disubstituted-1,3,4-oxadiazoles have been prepared. Their structures were confirmed by elemental analysis, IR and (13)C NMR spectral data. The antimicrobial properties of the compounds were investigated against bacterial strains i.e., Proteus mirabilis, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus and fungal strains i.e., Aspergillus niger and Candida albicans using disk diffusion method. Some of the compounds demonstrated marked antibacterial and antifungal activities. The efforts were also made to establish structure-activity relationships among the synthesized compounds.

引用

页码：25 / 28

页数：4

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