The Role of Hepcidin in Iron Metabolism

被引：423
|
作者：
Nemeth, Elizabeta [1 ]
Ganz, Tomas [1 ]
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
来源：
ACTA HAEMATOLOGICA | 2009年 / 122卷 / 2-3期
基金：
美国国家卫生研究院;
关键词：
Anemia of inflammation; Bone morphogenetic protein; Hemochromatosis; Hepcidin; Iron-loading anemia; HEREDITARY HEMOCHROMATOSIS PROTEIN; FERROPORTIN; ANEMIA; HYPOFERREMIA; HEMOJUVELIN; EXPRESSION; HORMONE; HFE;
D O I：
10.1159/000243791
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hepcidin is the central regulator of systemic iron homeostasis. Dysregulation of hepcidin production results in a variety of iron disorders. Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C. Hepcidin excess is associated with anemia of inflammation, chronic kidney disease and iron-refractory iron deficiency anemia. Diagnostic and therapeutic applications of this new knowledge are beginning to emerge. Dr. Ernest Beutler played a significant role in advancing our understanding of the function of hepcidin. This review is dedicated to his memory. Copyright (C) 2009 S. Karger AG, Basel
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收藏
页码：78 / 86
页数：9
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