Cyclohexanones by Rh-Mediated Intramolecular C-H Insertion

被引：27

作者：

Taber, Douglass F. ^{[1
]}

Paquette, Craig M. ^{[1
]}

Gu, Peiming ^{[1
]}

Tian, Weiwei ^{[1
]}

机构：

[1] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 19期

基金：

美国国家科学基金会;

关键词：

CARBON-HYDROGEN INSERTION; BETA-LACTAM ANTIBIOTICS; ENANTIOSELECTIVE SYNTHESIS; CYCLOPENTANE CONSTRUCTION; MOLECULAR COMPLEXITY; ASYMMETRIC-SYNTHESIS; NATURAL-PRODUCTS; BOND ACTIVATION; DIAZO KETONES; DESIGN;

D O I：

10.1021/jo4014996

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Some long chain alpha-aryl alpha-diazo ketones under Rh catalysis cyclize efficiently to the corresponding cyclohexanones. This is in marked contrast to the cyclizations of alpha-diazo beta-ketoesters, which consistently deliver cyclopentanone products.

引用

页码：9772 / 9780

页数：9

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