A high-yielding preparation of β-ketonitriles

被引：70
|
作者：
Ji, YH [1 ]
Trenkle, WC [1 ]
Vowles, JV [1 ]
机构：
[1] Brown Univ, Dept Chem, Providence, RI 02912 USA
来源：
ORGANIC LETTERS | 2006年 / 8卷 / 06期
关键词：
D O I：
10.1021/ol053164z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
beta-Ketonitriles are important precursors for a wide variety of biologically active heterocycles. A facile procedure for the high-yielding acylation of nitrile anions with unactivated esters to provide beta-ketonitriles is reported. The procedure is successful with enolizable and nonenolizable esters as well as hindered nitrile anions.
引用
收藏
页码：1161 / 1163
页数：3
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