Occult hepatitis B virus infection among injecting drug users in the Central-West Region of Brazil

被引：17

作者：

Dias de Matos, Marcia Alves ^{[1
]}

Ferreira, Renata Carneiro ^{[1
]}

Rodrigues, Fabiana Perez ^{[2
]}

Marinho, Tamiris Augusto ^{[1
]}

Rodrigues Lopes, Carmen Luci ^{[2
]}

Magalhaes Novais, Antonia Carlos ^{[4
]}

Coimbra Motta-Castro, Ana Rita ^{[3
]}

Teles, Sheila Araujo ^{[2
]}

Dutra Souto, Francisco Jose ^{[4
]}

Bringel Martins, Regina Maria ^{[1
]}

机构：

[1] Univ Fed Goias, Inst Patol Trop & Saude Publ, Goiania, Go, Brazil

[2] Univ Fed Goias, Fac Enfermagem, Goiania, Go, Brazil

[3] Univ Fed Mato Grosso do Sul, Dept Farm Bioquim, Campo Grande, MS, Brazil

[4] Univ Fed Mato Grosso, Fac Ciencias Med, Cuiaba, MT, Brazil

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2013年 / 108卷 / 03期

关键词：

hepatitis B virus; occult infection; genotypes; GENETIC DIVERSITY; VIRAL-HEPATITIS; HIGH PREVALENCE; RISK-FACTORS; GENOTYPES; EPIDEMIOLOGY;

D O I：

10.1590/S0074-02762013000300019

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The prevalence of occult hepatitis B virus (HBV) infection was investigated in 149 hepatitis B surface antigen (HBsAg) negative injecting drug users (IDUs) in the Central-West Region of Brazil. Of these individuals, 19 were positive for HBV DNA, resulting in an occult HBV infection prevalence of 12.7% (19/149); six of these 19 individuals had anti-HBV core and/or anti-HBV surface antibodies and 13 were negative for HBV markers. All IDUs with occult hepatitis B reported sexual and/or parenteral risk behaviours. All HBV DNA-positive samples were successfully genotyped. Genotype D was the most common (17/19), followed by genotype A (2/19). These findings reveal a high prevalence of occult HBV infection and the predominance of genotype D among IDUs in Brazil's Central-West Region.

引用

页码：386 / 389

页数：4

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