Glutathione-S-transferase activity in malarial parasites

被引：55
|
作者：
Srivastava, P [1 ]
Puri, SK
Kamboj, KK
Pandey, VC
机构：
[1] Cent Drug Res Inst, Div Biochem, Lucknow 226001, Uttar Pradesh, India
[2] Cent Drug Res Inst, Div Microbiol, Lucknow 226001, Uttar Pradesh, India
[3] Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India
来源：
TROPICAL MEDICINE & INTERNATIONAL HEALTH | 1999年 / 4卷 / 04期
关键词：
glutathione-S-transferase (GST); chloroquine-resistant (CQR); chloroquine-sensitive (CQS); Plasmodium; antimalarials; haem;
D O I：
10.1046/j.1365-3156.1999.00387.x
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Glutathione-S-transferase (GST) activity has been detected in rodent (Plasmodium berghei, P. yoelii), simian (P, knowlesi) and human (P. falciparum) malarial parasites, and in different intraerythrocytic stages of P. knowlesi (schizont > ring > trophozoite). In chloroquine-resistant strains of rodent and human malarial parasites GST activity significantly increases compared to sensitive strains. Further, the increase in enzyme activity is directly related to drug pressure of resistant P. berghei. Complete inhibition of chloroquine-sensitive and resistant P. berghei glutathione-S-transferase activities was observed at 2.5 and 5.0 mu m concentration of hemin, respectively. An inverse relationship was found between the heme level and enzyme activity of chloroquine-resistant and sensitive P. berghei. Chloroquine, artemisinin, and primaquine noticeably inhibited GST activity in P. knowlesi.
引用
收藏
页码：251 / 254
页数：4
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