Controlling cell-material interactions with polymer nanocomposites by use of surface modifying additives

被引：9

作者：

Poole-Warren, L. A. ^{[1
]}

Farrugia, B. ^{[1
]}

Fong, N. ^{[1
]}

Hume, E. ^{[1
]}

Simmons, A. ^{[1
]}

机构：

[1] Univ New S Wales, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia

来源：

APPLIED SURFACE SCIENCE | 2008年 / 255卷 / 02期

基金：

澳大利亚研究理事会;

关键词：

Polyurethane; Organosilicate; Biomaterial; Antibacterial; Platelet adhesion; Fibroblast adhesion;

D O I：

10.1016/j.apsusc.2008.06.062

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Polymer nanocomposites (NC) are fabricated by incorporating well dispersed nanoscale particles within a polymer matrix. This study focuses on elastomeric polyurethane (PU) based nanocomposites, containing organically modified silicates (OMS), as bioactive materials. Nanocomposites incorporating chlorhexidine diacetate as an organic modifier (OM) were demonstrated to be antibacterial with a dose dependence related to both the silicate loading and the loading of OM. When the non-antibacterial OM dodecylamine was used, both cell and platelet adhesion were decreased on the nanocomposite surface. These results suggest that OM is released from the polymer and can impact on cell behaviour at the interface. Nanocomposites have potential use as bioactive materials in a range of biomedical applications. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：519 / 522

页数：4

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