A porous scaffold from bone-like powder loaded in a collagen-chitosan matrix

被引：11
|
作者：
Cui, K [1 ]
Zhu, Y [1 ]
Wang, MH [1 ]
Feng, QL [1 ]
Cui, FZ [1 ]
机构：
[1] Tsinghua Univ, Dept Mat Sci & Engn, Beijing 100084, Peoples R China
来源：
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 2004年 / 19卷 / 01期
关键词：
scaffold; biocompatibility; osteoblasts; biomimetic preparation;
D O I：
10.1177/0883911504042121
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Porous scaffolds that mimic both the structure and composition of natural bone were prepared. Nano-hydroxyapatite particles were first synthesized through deposition of minerals on self-assembled collagen fibrils. The porous scaffolds were then fabricated by loading the self-assembled nanohydroxyapatite-collagen composite powder into a cross-linked collagen-chitosan matrix. Porosity, mechanical properties, and composition of the scaffolds were studied. Biocompatibility was demonstrated by comparing in vitro osteoblasts-cultures, MTT assays, and alkaline phosphatase activity between the synthesized scaffolds and the control sample.
引用
收藏
页码：17 / 31
页数：15
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