A porous scaffold from bone-like powder loaded in a collagen-chitosan matrix

被引：11
|
作者：
Cui, K [1 ]
Zhu, Y [1 ]
Wang, MH [1 ]
Feng, QL [1 ]
Cui, FZ [1 ]
机构：
[1] Tsinghua Univ, Dept Mat Sci & Engn, Beijing 100084, Peoples R China
来源：
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 2004年 / 19卷 / 01期
关键词：
scaffold; biocompatibility; osteoblasts; biomimetic preparation;
D O I：
10.1177/0883911504042121
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Porous scaffolds that mimic both the structure and composition of natural bone were prepared. Nano-hydroxyapatite particles were first synthesized through deposition of minerals on self-assembled collagen fibrils. The porous scaffolds were then fabricated by loading the self-assembled nanohydroxyapatite-collagen composite powder into a cross-linked collagen-chitosan matrix. Porosity, mechanical properties, and composition of the scaffolds were studied. Biocompatibility was demonstrated by comparing in vitro osteoblasts-cultures, MTT assays, and alkaline phosphatase activity between the synthesized scaffolds and the control sample.
引用
收藏
页码：17 / 31
页数：15
相关论文
共 50 条
  • [1] A bone-like nano-hydroxyapatite/collagen loaded injectable scaffold
    Huang, Zhi
    Tian, Jing
    Yu, Bo
    Xu, Yong
    Feng, Qingling
    BIOMEDICAL MATERIALS, 2009, 4 (05)
  • [2] Enhanced Angiogenesis in Porous Collagen-Chitosan Scaffolds Loaded with Angiogenin
    Shi, Haifei
    Han, Chunmao
    Mao, Zhengwei
    Ma, Lie
    Gao, Changyou
    TISSUE ENGINEERING PART A, 2008, 14 (11) : 1775 - 1785
  • [3] Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
    Sanapalli, Bharat Kumar Reddy
    Gounder, Kalaivani Chinna
    Ambhore, Nilesh Sudhakar
    Kuppuswamy, Gowthamarajan
    Krishnamurthy, Praveen Thaggikuppe
    Karri, Veera Venkata Satyanarayana Reddy
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2021, (174):
  • [4] Nano-TiO2/collagen-chitosan porous scaffold for wound repairing
    Fan, Xialian
    Chen, Keke
    He, Xichan
    Li, Na
    Huang, Jinbao
    Tang, Keyong
    Li, Yijin
    Wang, Fang
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2016, 91 : 15 - 22
  • [5] Bone Mesenchymal Stem Cells With Hepatocyte Growth Factor Loaded Collagen-Chitosan Scaffold as a Model for Hepatic Tissue Engineering
    Zheng, Cheng
    Xu, Xiao
    Zheng, Shusen
    TRANSPLANTATION, 2015, 99 : 143 - 143
  • [6] Investigation the Porous Collagen-Chitosan/Glycosaminoglycans for Corneal Cell Culture as Tissue Engineering Scaffold
    LI Qin-Hua
    Chinese Journal of Biomedical Engineering, 2005, (01) : 1 - 6
  • [7] Guided bone regeneration with asymmetric collagen-chitosan membranes containing aspirin-loaded chitosan nanoparticles
    Zhang, Jiayu
    Ma, Shiqing
    Liu, Zihao
    Geng, Hongjuan
    Lu, Xin
    Zhang, Xi
    Li, Hongjie
    Gao, Chenyuan
    Zhang, Xu
    Gao, Ping
    INTERNATIONAL JOURNAL OF NANOMEDICINE, 2017, 12 : 8855 - 8866
  • [8] Enhancement of the Stability and Biocompatibility of a Collagen-Chitosan Scaffold with Aloe vera
    Jithendra, P.
    Kalaivani, T.
    Mani, U.
    Rose, C.
    Mandal, A. B.
    ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 2011, 39 (01): : 85 - 85
  • [9] The effect of collagen-chitosan porous scaffold thickness on dermal regeneration in a one-stage grafting procedure
    Shi Haifei
    Wang Xingang
    Wu Shoucheng
    Mao Zhengwei
    You Chuangang
    Han Chunmao
    JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 2014, 29 : 114 - 125
  • [10] Hydroxyapatite/Collagen Bone-Like Nanocomposite
    Kikuchi, Masanori
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2013, 36 (11) : 1666 - 1669
12345