microRNAs are ligands of Toll-like receptors

被引：66

作者：

Chen, Xi ^{[1
]}

Liang, Hongwei ^{[1
]}

Zhang, Junfeng ^{[1
]}

Zen, Ke ^{[1
]}

Zhang, Chen-Yu ^{[1
]}

机构：

[1] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Jiangsu Engn Res Ctr MicroRNA Biol & Biotechnol, Nanjing 210093, Jiangsu, Peoples R China

来源：

RNA | 2013年 / 19卷 / 06期

基金：

中国国家自然科学基金;

关键词：

microRNA; Toll-like receptor; ligand; exosome;

D O I：

10.1261/rna.036319.112

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has long been known that microRNAs (miRNAs) can regulate target gene expression at the post-transcriptional level. Recent studies, however, have revealed that miRNAs can also be transported from donor cells to recipient cells, in which these RNAs function in a novel manner as ligands of Toll-like receptors. Here, we review the latest findings on these unconventional miRNAs, with special emphasis on their biological significance.

引用

页码：737 / 739

页数：3

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