Ambient ionization and miniature mass spectrometry system for chemical and biological analysis

被引：95
|
作者：
Ma, Xiaoxiao [1 ]
Ouyang, Zheng [1 ]
机构：
[1] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47906 USA
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2016年 / 85卷
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
Ambient ionization; Miniature mass spectrometer; Biomarker; Therapeutic drug monitoring; Quantitative analysis; DESORPTION ELECTROSPRAY-IONIZATION; HIGH-THROUGHPUT ANALYSIS; DRIED BLOOD SPOTS; PAPER-SPRAY; SURFACE SAMPLING/IONIZATION; INSTRUMENTATION DEVELOPMENT; QUANTITATIVE-ANALYSIS; NANO-ELECTROSPRAY; SAMPLING PROBE; ION-SOURCE;
D O I：
10.1016/j.trac.2016.04.009
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Ambien ionization and miniaturization of mass spectrometers are two fields in mass spectrometry that have advanced significantly in the last decade. The integration of the techniques developed in these two fields is leading to the development of complete miniature analytical systems that can be used for on site or point-of-care analysis by non-expert users. In this review, we report the current status of development in ambient ionization and miniature mass spectrometers, with an emphasis on those techniques with potential impact on the point-of-care (POC) diagnostics. The challenges in the future development of the integrated systems are discussed with possible solutions presented. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：10 / 19
页数：10
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