Characterization of biguanides by 15N NMR spectroscopy

被引：0
|
作者：
Clement, B [1 ]
Girreser, U [1 ]
机构：
[1] Univ Kiel, Inst Pharmazeut, D-24118 Kiel, Germany
来源：
MAGNETIC RESONANCE IN CHEMISTRY | 1999年 / 37卷 / 09期
关键词：
NMR; N-15; chemical shifts; polarization transfer; biguanides; hydrochlorides;
D O I：
10.1002/(SICI)1097-458X(199909)37:9<662::AID-MRC518>3.0.CO;2-D
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The monoprotonated biguanides phenformin hydrochloride, buformin hydrochloride and metformin hydrochloride were investigated by N-15 NMR spectroscopy. The structure of all hydrochlorides is best described by a 1,3-diazabutadienic skeleton with three amino groups and its corresponding mesomeric forms. There is no evidence for the presence of other tautomeric forms in solution. Copyright (C) 1999 John Wiley & Sons, Ltd.
引用
收藏
页码：662 / 666
页数：5
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