PAX5 alteration-associated gene-expression signatures in B-cell acute lymphoblastic leukemia

被引：4
|
作者：
Shang, Zhen [1 ]
Zhao, Yuechao [1 ]
Zhou, Kuangguo [1 ]
Xu, Yanling [1 ]
Huang, Wei [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Hematol, Wuhan 430030, Peoples R China
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2013年 / 97卷 / 05期
关键词：
PAX5; B-cell acute lymphoblastic leukemia; Bioinformatics; TRANSCRIPTION FACTOR PAX5; TUMOR-SUPPRESSOR; PROGNOSIS; DELETION;
D O I：
10.1007/s12185-013-1309-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The paired box domain gene 5 (PAX5) is frequently altered in both childhood and adult B-cell acute lymphoblastic leukemia, and takes part in leukemogenesis. We analyzed data from the database of Gene Expression Omnibus (accession number: GSE11877) using bioinformatical and statistical methods. The results showed that cases of PAX5 alteration can cluster using unsupervised clustering algorithms, and one gene, zinc and ring finger 1 (ZNRF1), was characterized and validated by quantitative RT-PCR. ZNRF1 may be associated with leukemogenesis of ALL with PAX5 alteration.
引用
收藏
页码：599 / 603
页数：5
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