Electrophysiological analysis of the interaction between the lateral septum and the central nucleus of the amygdala

被引：16
|
作者：
Thomas, Earl [1 ]
DeWolfe, Melissa [1 ]
Sancar, Feyza [1 ]
Todi, Nisha [1 ]
Yadin, Elna [1 ]
机构：
[1] Bryn Mawr Coll, Dept Psychol, Bryn Mawr, PA 19010 USA
来源：
NEUROSCIENCE LETTERS | 2012年 / 524卷 / 02期
关键词：
Lateral septum; Central nucleus; Amygdala; Single-unit; Negative feedback; UNIT-ACTIVITY; CONNECTIONS; FEAR; STIMULATION; COMPLEX; CORTEX;
D O I：
10.1016/j.neulet.2012.07.008
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Evidence suggests that the lateral septum (LS) and the central nucleus of the amygdala (CeA) play opposing roles in the modulation of fear and anxiety. The current study examined the interaction of the two structures in the albino rat by electrically stimulating each and recording single-unit activity in the other. In each case, electrical stimulation consisted of 50 trains of 5 pulses 800 mu A in amplitude, 0.1 ms in duration with a .01 s interval between pulses. Electrical stimulation of LS had a predominant inhibitory effect upon cells in CeA. Contrariwise, stimulation of CeA had a predominant excitatory effect on cells in LS. The results of the study suggest a possible regulatory, negative feedback model of the interaction between LS and CeA. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：79 / 83
页数：5
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