n-3 fatty acids, γ-linolenic acid, and antioxidants in sepsis

被引：17
|
作者：
Das, Undurti N. [1 ,2 ,3 ]
机构：
[1] UND Life Sci, Shaker Hts, OH 44120 USA
[2] Gayatri Vidya Parishad Coll Engn, Biosci Res Ctr, Visakhapatnam 533048, Andhra Pradesh, India
[3] Jawaharlal Nehru Technol Univ, Kakinada 533003, India
来源：
CRITICAL CARE | 2013年 / 17卷 / 02期
关键词：
EICOSAPENTAENOIC ACID; VENTILATED PATIENTS; OMEGA-3-FATTY-ACIDS; INFLAMMATION; DEFICIENCY; MEDIATORS; DIET;
D O I：
10.1186/cc12574
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
The usefulness of n-3 fatty acids, gamma-linolenic acid and antioxidants in the critically ill is controversial. I propose that adverse outcome in the critically ill is due to excess production of proinflammatory cytokines and eicosanoids from polyunsaturated fatty acids (PUFAs), while generation of anti-inflammatory products of PUFAs may lead to a favorable outcome. Hence, I suggest that measurement of plasma levels of various cytokines, free radicals, and proinflammatory and anti-inflammatory products of PUFAs and correlating them to the clinical picture may pave the way to identify prognostic markers and develop newer therapeutic strategies to prevent and manage critical illness.
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