Pharmacodynamic effects of amoxicillin versus cefotaxime against penicillin-susceptible and penicillin-resistant pneumococcal strains: A phase I study

被引：11
|
作者：
Aguilar, L
Rosendo, J
Balcabao, IP
Martin, M
Gimenez, MJ
Frias, J
Prieto, J
机构：
[1] UNIV AUTONOMA MADRID,DEPT THERAPEUT & PHARMACOL,MADRID,SPAIN
[2] UNIV COMPLUTENSE MADRID,SCH MED,DEPT MICROBIOL,MADRID,SPAIN
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 06期
关键词：
D O I：
10.1128/AAC.41.6.1389
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Serum bactericidal activity against a penicillin-susceptible strain and a penicillin-resistant strain of Streptococcus pneumoniae (amoxicillin and cefotaxime MICs, 0.001 and 1 mu g/ml, respectively, and MBCs, 0.01 and 2 mu g/ml, respectively) was measured in 12 healthy volunteers who each received an oral 875-mg dose of amoxicillin and an intramuscular 1-g dose of cefotaxime in a crossover fashion. The areas under the bactericidal activity-time curves for the two strains were found to be similar for both antibiotics despite the significantly higher (P < 0.002) AUC/MIC and peak level/MIC values for cefotaxime.
引用
收藏
页码：1389 / 1391
页数：3
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