On the possibility of shear-driven chromatography: a theoretical performance analysis

被引：47
|
作者：
Desmet, G [1 ]
Baron, GV [1 ]
机构：
[1] Free Univ Brussels, Dept Chem Engn, B-1050 Brussels, Belgium
来源：
JOURNAL OF CHROMATOGRAPHY A | 1999年 / 855卷 / 01期
关键词：
shear-driven chromatography; mobile phase flow;
D O I：
10.1016/S0021-9673(99)00652-4
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The use of shear forces for the generation of the mobile phase flow in chromatographic separations is proposed. This novel chromatographic operating principle, referred to as shear-driven chromatography (SDC), completely circumvents the pressure-drop limitation of conventional pressure-driven GC and LC without affecting the operational flexibility (choice of mobile and stationary phases, possibility of solvent and/or temperature programming, etc.). In the present paper, the expression for the height equivalent to a theoretical plate in SDC in a channel with a flat rectangular cross-section is established and is used to demonstrate the large gain in analysis speed under LC, GC and supercritical fluid chromatography conditions. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：57 / 70
页数：14
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