Structural implications in the function of L-type voltage-dependent calcium channels

被引:0
|
作者
Krizanova, O
机构
关键词
L-type Ca-channel; structure-function; expression;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The calcium channels play a key role in controlling many physiological processes in the body. Voltage dependent calcium channels have been extensively characterized in terms of their electrophysiological and pharmacological properties. The L-type voltage-dependent calcium channel is composed of several subunits, from which the alpha(1) subunit is the most important. Recent interest has been focused more on the functional implication of the subunit structures and/or their parts. Therefore, this review will concentrate on the structure-functional studies of the voltage-dependent calcium channel rather than on the progress in the study of their structure and tissue specificity.
引用
收藏
页码:79 / 87
页数:9
相关论文
共 50 条
  • [21] Galphai2-specific regulation of voltage-dependent L-type calcium channels (L-VDCC) in heart
    Dizayee, S.
    Kaestner, S.
    Kuck, F.
    Piekorz, R.
    Hein, P.
    Matthes, J.
    Nurnberg, B.
    Herzig, S.
    [J]. CARDIOVASCULAR RESEARCH, 2010, 87 : S104 - S104
  • [22] A simulation study of voltage-dependent inactivation in the cardiac L-type calcium channel
    Kurachi, Yoshihisa
    Suzuki, Shingo
    Murakami, Shingo
    Findlay, Ian
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2007, 42 : S20 - S20
  • [23] INCREASED L-TYPE VOLTAGE-DEPENDENT CALCIUM CURRENT IN NIDDM MODEL RAT
    KATO, S
    ISHIDA, H
    TSUURA, Y
    GOTO, M
    OKAMOTO, Y
    SEINO, Y
    [J]. DIABETES, 1993, 42 : A68 - A68
  • [24] The apparent voltage-dependent inactivation of cardiac L-type calcium channels seems to be a voltage-dependent block relieved upon repolarization following strong depolarizations.
    Fleig, A
    Muhlen, FVZ
    Penner, R
    [J]. BIOPHYSICAL JOURNAL, 1997, 72 (02) : WPO51 - WPO51
  • [25] STAC proteins inhibit calcium and voltage dependent inactivation of L-type calcium channels
    Tuinte, Wietske E.
    Tuluc, Petronel
    Flucher, Bernhard E.
    Campiglio, Marta
    [J]. BIOPHYSICAL JOURNAL, 2022, 121 (03) : 97 - 97
  • [26] Voltage-dependent calcium channels:: From structure to function
    Hofmann, F
    Lacinová, L
    Klugbauer, N
    [J]. REVIEWS OF PHYSIOLOGY BIOCHEMISTRY AND PHARMACOLOGY, VOL 139, 1999, 139 : 33 - 87
  • [27] Voltage-dependent calcium channels
    Lacinova, L
    [J]. GENERAL PHYSIOLOGY AND BIOPHYSICS, 2005, 24 : 3 - 78
  • [28] Cytoskeleton modulates the voltage-dependent inactivation of cardiac L-type Ca channels.
    Urata, M
    Nagao, T
    Adachi-Akahane, S
    [J]. BIOPHYSICAL JOURNAL, 1999, 76 (01) : A406 - A406
  • [29] L, P, and Q type voltage-dependent calcium channels in vascular myocytes
    Skott, O
    Andreasen, D
    Friis, UG
    Uhrenholt, TR
    Jensen, BL
    [J]. FASEB JOURNAL, 2006, 20 (04): : A304 - A304
  • [30] Multiple structural elements contribute to voltage-dependent facilitation of neuronal α1C (CaV1.2) L-type calcium channels
    Altier, C
    Spaetgens, RL
    Nargeot, J
    Bourinet, E
    Zamponi, GW
    [J]. NEUROPHARMACOLOGY, 2001, 40 (08) : 1050 - 1057