Structural implications in the function of L-type voltage-dependent calcium channels

被引:0
|
作者
Krizanova, O
机构
关键词
L-type Ca-channel; structure-function; expression;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The calcium channels play a key role in controlling many physiological processes in the body. Voltage dependent calcium channels have been extensively characterized in terms of their electrophysiological and pharmacological properties. The L-type voltage-dependent calcium channel is composed of several subunits, from which the alpha(1) subunit is the most important. Recent interest has been focused more on the functional implication of the subunit structures and/or their parts. Therefore, this review will concentrate on the structure-functional studies of the voltage-dependent calcium channel rather than on the progress in the study of their structure and tissue specificity.
引用
收藏
页码:79 / 87
页数:9
相关论文
共 50 条
  • [1] ACTIVATORS OF VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNELS
    RAMPE, D
    KANE, JM
    [J]. DRUG DEVELOPMENT RESEARCH, 1994, 33 (03) : 344 - 363
  • [2] NOVEL MECHANISM OF VOLTAGE-DEPENDENT GATING IN L-TYPE CALCIUM CHANNELS
    PIETROBON, D
    HESS, P
    [J]. NATURE, 1990, 346 (6285) : 651 - 655
  • [3] Impaired Control of L-Type Voltage-Dependent Calcium Channels in Experimental Hypertension
    Pinterova, M.
    Liskova, S.
    Dobesova, Z.
    Behuliak, M.
    Kunes, J.
    Zicha, J.
    [J]. PHYSIOLOGICAL RESEARCH, 2009, 58 : S43 - S54
  • [4] L-Type Voltage-Dependent Calcium Channels As Therapeutic Targets for Neurodegenerative Diseases
    Yagami, T.
    Kohma, H.
    Yamamoto, Y.
    [J]. CURRENT MEDICINAL CHEMISTRY, 2012, 19 (28) : 4816 - 4827
  • [5] Fluorinated dihydropyridines as candidates to block L-type voltage-dependent calcium channels
    Menezes Spadeto, Joao Paulo
    Freitas, Matheus P.
    Cormanich, Rodrigo A.
    [J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2022, 40 (24): : 13456 - 13471
  • [6] Halothane effects on human neuronal voltage-dependent L-type calcium channels
    Nikonorov, I
    RecioPinto, E
    Blanck, TJJ
    [J]. BIOPHYSICAL JOURNAL, 1996, 70 (02) : WP178 - WP178
  • [7] VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNELS IN THE DEVELOPMENT AND PLASTICITY OF MOUSE BARREL CORTEX
    GALEWSKI, S
    SKANGIELKRAMSKA, J
    POMORSKI, P
    KOSSUT, M
    [J]. DEVELOPMENTAL BRAIN RESEARCH, 1992, 67 (02): : 293 - 300
  • [8] The anesthetic bupivacaine induces cardiotoxicity by targeting L-type voltage-dependent calcium channels
    Gao, YaNan
    Chen, Bo
    Zhang, Xue
    Yang, Rui
    Hua, QingLi
    Li, BaiDong
    [J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2020, 48 (08)
  • [9] AN ANTIBODY TO L-TYPE CALCIUM CHANNELS REDUCES VOLTAGE-DEPENDENT CALCIUM CURRENT IN GUINEA-PIG CARDIAC MYOCYTES IN A VOLTAGE-DEPENDENT MANNER
    CAMPBELL, V
    TERRACCIANO, CMN
    NAQVI, RU
    BRICKLEY, K
    BALDWIN, SA
    MACLEOD, KT
    DOLPHIN, AC
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1995, 487P : P130 - P130
  • [10] VOLTAGE-DEPENDENT POTENTIATION OF NEURONAL L-TYPE CALCIUM CHANNELS DUE TO STATE-DEPENDENT PHOSPHORYLATION
    SCULPTOREANU, A
    FIGOUROV, A
    DEGROAT, WC
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1995, 269 (03): : C725 - C732