Acquisition of the trace-conditioned eye blink response (CR) is mediated by a variety of brain structures, including the cerebellum, the hippocampus, and brain stem nuclei. We examined the effects of a neuronal sodium channel antagonist (lamotrigine) on the ability of rabbits to acquire an eye blink CR after 6.5 min of cerebral ischemia. New Zealand white rabbits (n = 31) were randomly assigned to sham (S), normothermic ischemia (N), hypothermic (30 degrees C) ischemia-(H), or lamotrigine (50 mg/kg) treated (L) groups. In the N, H, and L groups, 6.5 min of global cerebral ischemia was produced using an inflatable neck tourniquet. Trace conditioning was started on the 7th postischemic day. The conditioned stimulus consisted of a tone (85 dB, 6 kHz) presented for 100 ms. The unconditioned stimulus was an air puff (150 ms duration) directed at the cornea. The interval between the end of the conditioned stimulus and the start of the unconditioned stimulus (the trace interval, TI) was 300 ms in duration. A trace-conditioned response was defined as an eye blink that was initiated during the TI. Eighty trials were delivered daily for 15 days. Neurologic deficits were greatest in the N group, and these animals had fewer CRs (149 +/- 157) than animals in the S (509 +/- 214) or H (461 +/- 149) groups (P < 0.05 by analysis of variance). Animals in the L group had a total number of CRs (380 +/- 253) that was intermediate between the S and N groups. Histologic evidence of neural injury was greatest in the N group. This study demonstrates that a brief episode of cerebral ischemia results in the impairment of this test of neurobehavioral function. Both hypothermia and lamotrigine were able to attenuate the impairment of eye blink trace-conditioned responses produced by cerebral ischemia. (C) 1999 Academic Press.
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Univ Yamanashi, Fac Med, Dept Anesthesiol, Chuo Ku, 1110 Shimokato, Kofu, Yamanashi 4093898, JapanUniv Yamanashi, Fac Med, Dept Anesthesiol, Chuo Ku, 1110 Shimokato, Kofu, Yamanashi 4093898, Japan
Kondo, Daisuke
Asano, Nobumasa
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Univ Yamanashi, Fac Med, Dept Anesthesiol, Chuo Ku, 1110 Shimokato, Kofu, Yamanashi 4093898, JapanUniv Yamanashi, Fac Med, Dept Anesthesiol, Chuo Ku, 1110 Shimokato, Kofu, Yamanashi 4093898, Japan
Asano, Nobumasa
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Ishiyama, Tadahiko
Shintani, Noriyuki
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Univ Yamanashi, Univ Yamanashi Hosp, Surg Ctr, Chuo Ku, Kofu, Yamanashi, JapanUniv Yamanashi, Fac Med, Dept Anesthesiol, Chuo Ku, 1110 Shimokato, Kofu, Yamanashi 4093898, Japan
Shintani, Noriyuki
Matsukawa, Takashi
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Univ Yamanashi, Fac Med, Dept Anesthesiol, Chuo Ku, 1110 Shimokato, Kofu, Yamanashi 4093898, JapanUniv Yamanashi, Fac Med, Dept Anesthesiol, Chuo Ku, 1110 Shimokato, Kofu, Yamanashi 4093898, Japan
机构:
Third Mil Med Univ, Coll Basic Med Sci, Dept Physiol, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Coll Basic Med Sci, Dept Physiol, Chongqing 400038, Peoples R China
Hu, Bo
Chen, Hao
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Third Mil Med Univ, Coll Basic Med Sci, Dept Physiol, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Coll Basic Med Sci, Dept Physiol, Chongqing 400038, Peoples R China
Chen, Hao
Feng, Hua
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Third Mil Med Univ, Southwest Hosp, Dept Neurosurg, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Coll Basic Med Sci, Dept Physiol, Chongqing 400038, Peoples R China
Feng, Hua
Zeng, Yuan
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Third Mil Med Univ, Coll Basic Med Sci, Dept Physiol, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Coll Basic Med Sci, Dept Physiol, Chongqing 400038, Peoples R China
Zeng, Yuan
Yang, Li
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Third Mil Med Univ, Coll Basic Med Sci, Dept Physiol, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Coll Basic Med Sci, Dept Physiol, Chongqing 400038, Peoples R China
Yang, Li
Fan, Zheng-li
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Third Mil Med Univ, Coll Basic Med Sci, Dept Physiol, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Coll Basic Med Sci, Dept Physiol, Chongqing 400038, Peoples R China
Fan, Zheng-li
Wu, Ya-min
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Third Mil Med Univ, Inst Surg Res, State Key Lab Trauma Burns & Combined Injury, Daping Hosp,Dept 3, Chongqing 400042, Peoples R ChinaThird Mil Med Univ, Coll Basic Med Sci, Dept Physiol, Chongqing 400038, Peoples R China
Wu, Ya-min
Sui, Jian-feng
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Third Mil Med Univ, Coll Basic Med Sci, Dept Physiol, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Coll Basic Med Sci, Dept Physiol, Chongqing 400038, Peoples R China